Correlation between serum uric acid level and microangiopathic complications in patients with type 2 diabetes mellitus
Journal Title: MedPulse -International Medical Journal - Year 2018, Vol 5, Issue 1
Abstract
Introduction: Diabetes is a metabolic disorder with multiple microvascular complications such as retinopathy, neuropathy and nephropathy. Hyperuricemia has been found to be associated with these microvascular complications in Southeast Asian countries, but its prevalence in South Indian diabetics is unknown. Aims and objectives: Primary objective: To identify the association between serum uric acid levels (SUA) and microangiopathic complications in patients with type-2 Diabetes Mellitus. Secondary objective: To study the association of risk factors such as age, duration of diabetes, FBS, PPBS and HbA1c with uric acid levels. Materials and Methods: 50 patients attending the medicine outpatient department or admitted in the medicine ward were interviewed and a detailed history, relevant clinical examination including BMI was carried out. FBS, PPBS, HbA1c, serum uric acid and serum creatinine were done. Assessment of microvascular complications was done using urine spot PCR for nephropathy, NCS for neuropathy and detailed fundus examination for retinopathy. Results: 50 patients with a mean age of 54.5 ± 11.5 years were included in the study of which 52% were males and 48% females. Diabetic retinopathy, nephropathy and neuropathy were found in 56%, 38% and 40% of patients respectively. Mean duration of diabetes was 8.2 ± 5.5 years. The SUA levels were found to be higher in patients with retinopathy than those without retinopathy (6.7 ± 1.6 vs 5.1 ± 1.35) mg/dl which was statistically significant (p < 0.001). A similar difference was found in patients with and without neuropathy (7.1 ± 1.5 vs 5.3 ± 1.4)mg/dl (p < 0.0001). However there was no statistically significant difference in SUA levels in patients with nephropathy. Correlation of SUA levels with other risk factors such as FBS, PPBS and HbA1c, age, duration of diabetes and BMI revealed that FBS and age had a statistically significant positive correlation with SUA (p = 0.043 and p = 0.027) respectively. Conclusion: SUA levels are higher in patients with microvascular complications of type 2 DM such as retinopathy, neuropathy and nephropathy. Further, higher FBS and increasing age are found to be associated with higher uric acid levels.
Authors and Affiliations
Sarah S Premraj, Padmanabhan K, Durga Krishnan, Mayilananthi K, Rajasekaran D, Udayashankar D
Keywords
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