Correlation between T Stage of the Tumor and Tumor Behavior in Locally Advanced Head and Neck Squamous Cell Carcinoma
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 8
Abstract
<strong>Background: </strong>Head and neck cancer (HNC) represents more than 550,000 cases annually. It accounts for 380,000 deaths every year. Despite aggressive treatment, only 35% to 55% of patients who present with locally advanced HNC remain alive and free of disease 3 years after standard curative treatment. Thirty percent to 40% of patients develop locoregional recurrences, and distant metastases occur in 20% to 30%. Most recurrences appear quickly within 2 years of initial treatment and an additional 10% of patients will have evidence of distant metastases at the time of first presentation. <strong>Purpose: </strong>To retrospectively determine the prognostic effect of T stage in locally advanced head and neck cancer. <strong>Patients and Methods: </strong>This study retrospectively analyzed 40 patients diagnosed with locally advanced head and neck cancer. Patients were diagnosed by a tissue biopsy and they were staged by endoscope and CT neck or MRI neck with contrast. They received their treatment and were followed up every 3 months by CTs. <strong>Results: </strong>We found a statistically significant correlation between T stage and both PFS and OS in HNC (95%, CI 1.00 – 3.10, p=0.04 and 95% CI 1.01 – 2.65, p=0.05 respectively). We did not find any other statistically significant correlation between other patients’ sub-groups such as age, gender, smoking, affected site, stage, lymph node infiltration, receiving induction chemotherapy, receiving radiotherapy with or without chemotherapy, and response to treatment and between PFS and OS. <strong>Conclusion: </strong>This study confirmed that the T stage of the tumor is an important prognostic factor in locally advanced head and neck cancer.
Authors and Affiliations
Eman Helal
Keywords
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- EP ID EP584276
- DOI 10.12816/ejhm.2018.10277
- Views 93
- Downloads 0
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