Correlation between the Prevalence of Hepatitis B and C Viruses against Tumor Necrosis Factor- α among Patients in Babylon Province
Journal Title: Microbiology Research Journal International - Year 2016, Vol 12, Issue 3
Abstract
Background: Hepatitis is a liver disease caused by infectious and non-infectious agents. Hepatitis B and C are major public health problems worldwide. Hepatitis B (HBV) and C virus (HCV) infections are known to occur in the general population due to their multiple mode of transmission mainly through blood. Aim: This study aimed to estimate the prevalence of hepatitis B and C virus among population in Babylon province and evaluation of the levels of the TNF-alpha in infected patients with hepatitis B and C Methods: The study was conduced on individuals referred to the Central Public Health Laboratory to investigate the prevalence of HBV and HCV infections in Babylon province. A total of 6061 samples was included in this study, they screened by VIDAS test for detection of both viruses, then confirmed by real- time PCR. Concentration of TNF- α was measured in patients with hepatitis B and C and control group (Control group consisted of the healthy subjects with no history of renal or liver diseases and negative results for HBV and HCV test) by using ELISA test. Results: A total of 6061 individual were screened, amongst them, 18 (0.29%) were positive for HBV and 16 (0.26%) were positive for HCV by both VIDS test and real-time PCR. Most of HBV infections seen among hemodialysis patients followed by haemophila, while most HCV infections seen among thalasemia and haemophila patients than others groups. The prevalence of both viruses was higher among male than female, and in urban than rural rejoin. Most of HBV infections were high in individual with age ranging between 20-29 and 30-39 years, while most HCV infections in individual with age ranging between 20-29 years, although it is statistically insignificant. The mean serum level of TNF- α was significantly higher in individual with HBV and HCV infection (68.7±12.84 pg/mL) and (89.1±22.017) as compared with control group (43.1±5.87 pg/mL). Conclusion: The prevalence of HBV and HCV was relatively low. There are increasing level of TNF-α in the serum of patients with viral hepatitis B and C.
Authors and Affiliations
Rasha Hadi Saleh, Bara Hamid Hadi
Keywords
Related Articles
- EP ID EP350676
- DOI 10.9734/BMRJ/2016/22185
- Views 66
- Downloads 0
Microbial Response to Varying Concentrations of Crude Oil Pollution of Agricultural Soils in Ondo State, Nigeria
This research investigated the effects of varying concentrations of crude oil on the population of crude oil degrading microorganisms in crude oil polluted agricultural soils from Igodan- Lisa, Oba-Ile and Ido-Ani areas...
Prevalence of Methicillin-resistant Staphylococcus aureus among Health Care Workers in Tripoli Hospital, Libya
Aims: Staphylococcus aureus is a common cause of community and a hospital infection, methicillin-resistant Staphylococcus aureus (MRSA), is a common nosocomial infection pathogen, its resistance to multiple antibiotics h...
Poultry Environment as a Reservoir of Antimicrobial Resistant Bacteria – A Nigerian Story
Aims: This study set out to help define the role of the poultry environment as a reservoir of drug resistant bacteria in Nigeria. Introduction: The poultry environment has been acclaimed as a potential source of antimicr...
Molecular Analysis of Staphylococcus aureus Infections in Trinidad and Tobago
Aims: Previous studies regarding Staphylococcus aureus in Trinidad and Tobago have so far been conducted mainly on methicillin resistant S. aureus (MRSA) isolates. Few reports are available regarding S. aureus infections...
A New Antibiotic Adjuvant Entity (Ceftriaxone + Sulbactam + Disodium Edetate): An Alternative to Carbapenems for the Management of Intensive Care Unit Infection
Aims: Carbapenem resistant bacterial infections have limited treatment options and are associated with high mortality. Here we present a retrospective analysis of treatment and outcome for ICU patients suffering from mod...