Correlation between Thyroid Dysfunction and Oxidative Stress in Undialyzed Chronic Renal Failure Patients
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 5
Abstract
Background and Aim: Patients with chronic kidney disease (CKD) often have subclinical hypothyroidism. However, few reports have investigated changes in the status of subclinical hypothyroidism in CKD patients This study aimed to investigate the relationship between oxidative stress and thyroid hormones status in patients with chronic renal failure (CRF). Methods: Thyroid hormones and renal function parameters like serum urea, creatinine, and oxidative stress malandialdehyde (MDA) as oxidant and total vitamin-C as antioxidant were estimated and correlations between thyroid hormones, oxidative stress and renal function parameters were studied in 30 undialyzed chronic kidney disease patients’ verses 30 healthy controls. Results: We found both T3 and T4 were significantly reduced (p<0.05) whereas the serum TSH concentration was increased among those with CKD patient group compared to controls (p<0.05). We also observed that urea and creatinine were significantly increased among those with CKD patient than in the controls at (p<0.05) level. In addition, patients had lower total vitamin -c than the controls at (p<0.05) level, The MDA in the CKD patients was significantly increased than in the controls at (p<0.05) level. Conclusion: From our data, we concluded that renal insufficiency may lead to thyroid hormone disturbances and CKD appears to enhance the oxidative stress due increased uremia levels
Authors and Affiliations
AV Swarajya Lakshmi
Keywords
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