Correlation of Anti-Mullerian Hormone with clinical, hormonal and ultrasonographic parameters in PCOS and normo-ovulatory women
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 2
Abstract
Objective:-To compare the serum AMH levels in PCOS and normo-ovulatory women and investigate the correlation between clinical, hormonal, ultra-sonographic parameters and AMH levels in both groups. Method:-A comparative cross sectional study was conducted at Pacific Medical College and Hospital, Udaipur, Rajasthan during the period 15 October 2015 to April 2016 . A total of 64 women of reproductive age (21–35 years) were recruited for study after taking informed consent and were divided into 32 Case (PCOS patients defined by the Rotterdam criteria) and 32 Control (non-PCOS patients) groups. Menstrual history, clinical manifestations of hyperandrogenism, transvaginal ultrasound assessments for ovarian follicles , and the levels of AMH, LH, FSH, and estradiol were collected. Results:- Thirty-two cases and 32 controls were recruited. AMH serum levels were significantly higher in PCOS patients than in controls. The Area Under the Curve (AUC) of the serum AMH assay in PCOS patients reached a value of 0.870. With a cut-off value of 4.45 ng/ml, the serum AMH level had a sensitivity of 76.1 % and a specificity of 74.6 %. The most common phenotypes of PCOS in this study were anovulation and polycystic ovary (63.4 %). However, the mean level of AMH was highest in the phenotypes of anovulation, polycystic ovaries and hyperandrogenism (11.1 ng/ml). Conclusion:-AMH can be used as an alternative diagnostic criteria for PCOS patients with a cut-off value of 4.45 ng/ml. AMH value rise when hyperandrogenism is present therefore serum AMH levels also reflect the phenotype of PCOS
Authors and Affiliations
Dr. Rajrani Sharma, Dr. Kanika Chandra, Dr. Archna Sharma
Keywords
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