CORRELATION OF DISEASE DURATION, SMOKING PACK YEARS AND FEV1% PREDICTED WITH VEP PARAMETERS IN PATIENTS OF COPD.
Journal Title: International Journal of Basic and Applied Physiology - Year 2016, Vol 5, Issue 1
Abstract
Background & Objectives: The most common risk factor for COPD is tobacco smoking. Inhaled noxious particles cause chronic inflammation in lungs and airways leading to persistent airflow limitation causing hypoxemia. . It not only affects the lungs but also affects the various body systems. Thus COPD is multisystem disorder. Visual evoked potential is useful for subclinical detection of visual impairment. The purpose of study was to correlate duration of COPD, smoking pack years and FEV1% with VEP parameters in COPD patients. Method: Spirometry was done to diagnose COPD. Pattern reversal VEP was conducted in 50 COPD patients who were smokers & 50 normal healthy subjects who were non-smokers. VEP parameters (P100 latency & amplitude) were assessed. Unpaired t-test and Pearson’s correlation test was used. Results: We found significant correlation between VEP parameters with smoking pack years & FEV1% predicted value. While no significant correlation with duration of disease. Interpretation & Conclusion: Findings suggest longer disease duration alone could not have significant effect in impairment of visual functioning while more smoking pack years & severe airflow obstruction can cause impaired visual pathway in COPD. It is because of ventilationperfusion imbalance causing hypoxemia leading to tissue hypoxia which decreases cerebral perfusion
Authors and Affiliations
Rubiya Shaikh, Rupali Parlewar
Keywords
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