Correlation Of Glycemic Status With Indicators Of Myocardial Oxygen Usage
Journal Title: International Journal of Basic and Applied Physiology - Year 2013, Vol 2, Issue 1
Abstract
Background: Present study aimed to investigate the correlation between poor glycemic control determined by glycosylated haemoglobin( A1C) and myocardial oxygen demand. Method: Case-control study comprised of three groups of 50 each age matched (30-45 yrs) normoglycemics, prediadetics and type 2 diabetic mellitus (T2DM) as per American Diabetic Association 2011 (ADA) criteria. The haemodynamic determinants of myocardial oxygen demand measured were heart rate(HR), systolic blood pressure(SBP) and rate pressure product(RPP) Result: The observations revealed significant differences in the fasting plasma glucose(FPG) and glycosylated haemoglobin (A1c) in the three groups. The resting HR was significantly higher in patients with T2DM (91.06±4.72 bpm;p=<0.0001) in comparison with controls and prediabetics. The SBP values (mm Hg) were in prehypertensives range in prediabetics and T2DM patients (125.5±4.0; 130.6±5.2). The RPPwas estimated to be significantly higher in T2DM (11922.9±1091.2) compared to prediabetics and controls (10197.6±806.1;8186.8±635.3). Positive correlation was found between resting HR(r=0.97,0.98) and RPP(r=0.98,0.98) with FPG levels in prediabetic and T2DM patients. Similar positive correlation was established between resting HR(r=0.96,0.95) and RPP(r=0.97,0.95) with A1c values. Conclusion: Heightened resting HR and RPP in prediabetics and T2DM patients suggest increased myocardial oxygen demand. These haemodynamic derangements render them vulnerable to adverse outcomes.
Authors and Affiliations
Asha Shrivastava , Sanjay Wasnik , Rashmi Dave
Keywords
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