Correlation of Glycosylated Hemoglobin (HbA1c) and Mean Platelet Volume (MPV) in Type II Diabetes Mellitus patients and Non Diabetic subjects
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2017, Vol 5, Issue 11
Abstract
Background: Type II Diabetes Mellitus (T2DM) is one of the pandemics in the modern era. It is a metabolic disease which leads to macrovascular complications like Coronary Artery Disease (CAD). HbA1c laboratory test is used to diagnose DM and to assess control in diabetes mellitus. Large platelets are more thrombogenic and put the patient at higher risk. Mean Platelet Volume (MPV) is the determinant of platelet functionality and increased MPV is associated with increased risk of macrovascular complications like myocardial infarction, stroke and Transient Ischaemic Attacks (TIA). Aims and Objectives: To study the HbA1c levels and mean platelet volume in Type II Diabetes Mellitus patients and nondiabetic subjects. To correlate HbA1c levels and MPV in T2DM patients and nondiabetic subjects. Materials and metod: This study was undertaken at D.Y. Patil Medical College, Hospital and Research Institute, Kolhapur. The duration of study was from May 2015 to April 2017. Total sample size was 110 out of which 56 were patients with T2DM and 54 were non-diabetic control subjects. Type II DM patients attending the outdoor and indoor patient department of D.Y.Patil Hospital, Kolhapur were taken as sample (cases).This is a cross sectional study. Only known cases of Type II Diabetes Mellitus without any cardiovascular manifestation were included in the study. Non-diabetic asymptomatic cases as sample control. A detailed history with thorough clinical examination was carried out. HbA1c and MPV investigations were carried out in all subjects (both groups). Results: MPV in T2DM patient group was 9±0.9 fl.; MPV in the non-diabetic group was 8.08±0.45 fl. Comparison of MPV values in two groups show statistically significant difference and p values < 0.0001. Conclusion: MPV was found to be higher in T2DM patients. Increased MPV was associated with higher HbA1c values. MPV can be used as a prognostic marker of vascular complications in patients with T2DM.
Authors and Affiliations
Mukund W Pujari, Padmaja R Desai
Keywords
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