Correlation of HbA1c with atherogenic index of plasma and endothelial dysfunction in type 2 diabetic subjects
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2018, Vol 5, Issue 4
Abstract
Introduction Endothelial dysfunction ED is a well known initial stage of atherosclerosis and cardiovascular disease CVD in general population Recently studies shown increased HbA1c is a marker for cardiovascular risk in subjects with diabetes and without diabetes Atherogenic index of plasma AIP is another risk factor for cardiovascular events Hence the study has been designed to assess the correlation of HbA1c with AIP and ED in type2 diabetic subjects to forecast risk of cardiovascular eventsMaterials and Methods Hundred subjects are enrolled into study with the age of 38 to 58 years among these 50 were type 2 diabetic subjects and 50 were healthy controls HbA1c was estimated by immunoturbidimetric method Nitric oxide NO was measured by kinetic cadmium reduction method and AIP was calculated by standard formula Log triglycerideHDLc Kruskal Wallis test was used to perform statistical variables between the study groups The association between the variables was executed by Pearson correlation testResult HbA1c level was shown to be significantly higher in type2 diabetic subjects than healthy controls Significant lower level of NO was observed in type2 diabetic subjects than healthy controls AIP level was significantly higher in type2 diabetic subjects than healthy controls The present study also observed significant correlation of HbA1c with NO and AIPConclusion We have found that HbA1c has significant correlation with NO and AIP Therefore estimation of HbA1c may be a predictable marker for cardiovascular events in type2 diabetic subjectsKeywords Glycated hemoglobin Atherogenic index of plasma Nitric oxide Cardiovascular disease
Authors and Affiliations
Veluri Ganesh, Palem Siva Prasad
Keywords
Related Articles
- EP ID EP475436
- DOI 10.18231/2394-6377.2018.0123
- Views 82
- Downloads 0
The synergistic role of CKMB mass and high sensitivity Troponin T in the diagnosis of Acute Coronary Syndrome
Aim: To determine the synergistic role of CKMB mass (CKMBM) and high sensitivity Troponin T (hs-cTnT) in the diagnosis of Acute Coronary Syndrome (ACS). Study Design: This was a cross-sectional study comprising of 140 in...
Study of serum adiponectin and lipid profile in newly diagnosed hyperthyroid patients
Introduction: Thyroid dysfunction is associated with metabolic changes that affect lipid and carbohydrate metabolism as well as adipocyte function. Adiponectin, an adipocyte derived hormone has been shown to decrease bod...
A study on role of Oxidative stress and Calcium-Phosphorous Ratio in Rheumatoid Arthritis
Background: Rheumatoid arthritis is one of the chronic inflammatory disease affecting joints and other organs is primarily of an unknown etiology with an incidence of 1% to 2% of total world population.one of the current...
Evaluation of serum uric acid in type two diabetic nephropathy patients
Introduction Diabetic nephropathy is one of the leading complications of longstanding diabetes mellitus With the background of inflammation there is need for laboratory tests for early diagnosis and prevention of diabeti...
The role of endothelin-1 and nitric oxide affecting endothelial dysfunction in the etiopathogenesis of ischaemic heart disease
Introduction Endothelial dysfunction is an imbalance in bioavailability ofendotheliumderived relaxing Nitric Oxide and contracting factors Endothelin Studies have shown that NO has antiatherogenic property as it inhibits...