Correlation of hepatocellular carcinoma with Hepatitis virus C, HBsAg and alcohol.
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2016, Vol 2, Issue 6
Abstract
Alcohol intake has been definitely recognized as a cause of chronic liver diseases, including hepatocellular carcinoma (HCC) (1, 2). Alcohol could be involved in the development of HCC through both direct (genotoxic) and indirect mechanisms. An indirect mechanism includes the development of cirrhosis, which is probably the most common pathway to liver carcinogenesis in developed countries (3). We found that 87 percent of the cases of HCC developed in a cirrhotic liver, including most of those attributable to alcohol intake (4). No evidence exists on the dose-effect relation between alcohol intake and risk of HCC. Some authors argue that the risk of developing liver disease does not increase over a threshold alcohol intake of about 75 g per day (5). Liver damage due to alcohol has been suspected on the basis of metabolic differences (6). Other aspects of the relation between alcohol drinking and HCC are still unresolved, namely, the effects of type of alcoholic beverage usually consumed, duration of drinking, age at start, and time since quitting. Synergisms between alcohol and hepatitis B virus infection and between alcohol and hepatitis C virus infection in increasing the risk of HCC have been suggested by epidemiologic and pathologic studies (10, 11). However, we know of no data available on the pattern of this interaction for various levels of alcohol intake.
Authors and Affiliations
Dr. Anil Batta Dr. Anil Batta
Keywords
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