Correlation of histopathological and anatomical changes in placenta with intrauterine growth restriction
Journal Title: The Indian Practitioner - Year 2016, Vol 69, Issue 5
Abstract
Background: Placenta is a vital organ for maintaining pregnancy and promoting normal growth by transfer of essential nutrients between foetus and mother. Any morphological alteration of the placenta affects the growth of foetus leading to intrauterine growth restriction (IUGR). The purpose of this study was to find out morphological and histopathological changes of placenta and to evaluate correlation of IUGR and placental histology. Material and methods: This study included 200 pregnant patients whose foetuses had intrauterine growth restriction and 200 patients with normal foetal growth. Gross and histopathological features of placentas of both groups were studied, analysed by student’s t test and compared with chi square test. p values of < 0.05 were considered significant. Results: Gross features, weight, thickness and calcification in study group show significant increase in value (p < 0.05) compared to control group and histopathology of placenta in study group also shows significant increase in syncytial knots formation, cytotrophoblastic proliferation, stromal fibrosis and calcification as compared to control group. Conclusion: To conclude, whatever may be the cause of IUGR, these morphological and histopathological changes lead to decrease blood to the placenta and this restriction of blood flow ultimately causes IUGR in the foetus
Authors and Affiliations
N Shrivastava, S Yadav
Keywords
Related Articles
- EP ID EP569417
- DOI -
- Views 47
- Downloads 0
Tamsulosin for the treatment of Voiding Dysfunction in Women – A Review
Lower urinary tract symptoms (LUTS) have high prevalence worldwide in the aging population including both, men and women and with the advancing age, the incidence of LUTS continues to increase. Interference of the sympto...
A case of Thalassaemia Major with Mucopolysaccharidosis
We present a case of a male infant, with Thalassaemia Major who also had facial dysmorphism suggestive of Mucopolysaccharidosis, which was detected with a urinary screening test. This is probably the first time that two...
Streptomycin monoresistant extrapulmonary tuberculosis in an immunocompetent healthcare worker– A case report
Tuberculosis (TB) is a major health problem in India and extrapulmonary tuberculosis (EPTB) comprises 20% of all cases of TB. EPTB is more common in HIV positive individuals and immunocompromised patients. In immunocompe...
Evans Syndrome – The diagnosis of exclusion
Evans Syndrome (ES) is a rare disease characterized by the simultaneous or sequential development of autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP) and/or immune neutropenia. We present a case of wo...
Rosenthal-Kloepfer Syndrome
Rosenthal-Kloepfer syndrome is a very rare disorder characterized by acromegaloid features, furrowed skin on scalp and face and corneal leukomas. Here we are presenting this rare syndrome in a man who presented with bila...