Correlation of Insulin Resistance and Serum Leptin in Metabolic Syndrome
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 3
Abstract
The metabolic syndrome mostly represented by obesity, hypertriglyceridemia and reduced level of HDLC. Obesity and hyperinsulinemia connected with insulin resistance, present the main mechanism in the pathogenesis of CVD. The present study was designed to compare the fasting leptin level with the insulin and insulin resistance between metabolic syndrome patients and healthy subjects. The present study included 140 metabolic syndrome cases (81 men and 59 women) and 100 healthy controls. Metabolic syndrome cases were diagnosed by (NCEP ATP III) criteria. Serum leptin, insulin, glucose and lipid profile measured and insulin resistance and BMI were calculated. All the parameters were significantly (P<0.0001) high in metabolic cases excepts HDL-C which was significantly (P<0.0001) low. Serum leptin level was significantly (P<0.0001) high in metabolic women compare to metabolic men. The correlation of leptin with insulin, and BMI were strong in both sexes. Increased leptin level shows positive correlation with regards to the metabolic component except the HDL which was decreased. The present study concluded that increased leptin level observed in metabolic cases, more in women compare to men and level increased with the obesity increases. So leptin can be sign of hyperinsulinemia, insulin resistance and disturbance in lipid metabolism that are associated with CVD and type 2 DM.
Authors and Affiliations
Rajkumari Rathore
Keywords
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