Correlation of levels of Prostate Specific Antigen with Histopathological findings in patient diagnosed with prostate adenocarcinoma: A study from Central India
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 6
Abstract
Introduction: Prostate cancer is the second most common malignant tumor in western males and anatomically involves the prostate peripheral zone. It is the most common type of cancer in men. To prevent an equal rise in mortality, early detection of prostate cancer will become essential, as will the detection of premalignant lesions such as prostatic intraepithelial neoplasia. Prostate cancer can only be diagnosed by thorough histopathological examination of prostatic tissue along with serum PSA levels estimation. Material and Methods: A Cross sectional study done over a period of 18months, was carried out on 150 prostate specimens. The specimens were examined for various prostatic pathologies by doing histopathological examination & their serum total PSA values were correlated. Patients diagnosed as prostate adenocarcinoma were included. On the contrary inadequate biopsy material cases, autolyzed specimen and patients younger than 40 years were not included. Results: Amongst 38 (25.3%) adenocarcinoma cases, 15 cases (10.0%) were well differentiated, 08 cases (5.3%) were intermediate grade, 03 cases (2.0%) were moderately to poorly differentiated and 12 cases (8.0%) were poorly differentiated. Discussion: The percentage of occurrence of occult carcinoma has significantly decreased over the years due to advanced investigative procedures like TRUS, serum PSA level estimation etc. Conclusion: A combination of staging, grading and follow- up study is required to obtain best predictive values.
Authors and Affiliations
Dr Anshu Hotani
Keywords
Related Articles
- EP ID EP493920
- DOI -
- Views 46
- Downloads 0
Chemokines Profile in Patients with Graves Diseases in Comparison to Nonautoimmune Hyperthyroidism in Al-Najaf Province
Graves' disease (GD), a form of hyperthryroidism (overactive thyroid gland), typified by auto antibodies directed against the thyroid stimulating hormone receptor (TSHR), Thyroid peroxidase (TPO) and thyroglobulin (Tg) (...
Study of Outcome of Subsequent Pregnancy following previous Caesarean Section in Katihar Medical College & Hospital, Katihar
Objectives: Our study was to evaluate the mode of delivery, operative difficulties of post caesarean section pregnancy, Frequency of postpartum complication, foetal and maternal morbidity and mortality in post caesarean...
An Observational Study Comparing the Correlation of Vertical Cup Disc Ratio and Disc Damage Likelihood Scale with Visual Field Changes and Central Corneal Thickness in Primary Open Angle Glaucoma Patients
Background: The current management of primary open angle glaucoma involves cutting edge diagnostic technology but the clinical examination of the optic disc still remains the mainstay of both diagnosis and therapy. The d...
Perioperative Morbidity of Endometrial Cancer: A Main Research Article
Purpose of the study: This study was undertaken to evaluate the perioperative morbidity in women undergoing surgery for carcinoma endometrium in a tertiary hospital in South India for a period of 5 years (2007-2012). Des...
Self-directed E-Learning in Under Graduate Medical Teaching
Introduction: E-learning or internet based learning, in various forms, is being implemented as a teachinglearning method and is hypothesized to replace traditional learning methods. In this context, there are questions r...