Correlation of Osteocalcin Level with Blood Glucose Concentration and Insulin Level in Type II Diabetic Sudanese Patients
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2017, Vol 6, Issue 10
Abstract
Osteocalcin, a bone-derived protein, has recently been reported to affect energy metabolism, this study aimed to evaluate the effects of osteocalcin level on blood glucose concentration and insulin level in type II diabetic Sudanese patients. In this cross-sectional study, one hundred ffteen type II diabetic patients were enrolled in the study (34 males and 81 females) with ages ranging between 18 and 90 years. Total osteocalcin, undercarboxylated osteocalcin, and insulin were measured using ELISA technique. Fasting blood glucose and lipid profle were measured by a spectrophotometer. Mean serum osteocalcin concentration in diabetic patients was signifcantly lower than those in control subjects (p ≤ 0.001). Undercarboxylated osteocalcin in diabetic patients was signifcantly lower than in control subjects (p ≤ 0.001). Fasting insulin was signifcantly higher in diabetic subjects compared to control subjects (p ≤ 0.001). Osteocalcin was negatively correlated with insulin and FBS (r = −0.530; p ≤ 0.001), (r = −0.373; p ≤ 0.001) respectively. Undercarboxylated was negatively correlated with insulin and FBS (r = −0.634; p ≤ 0.001), (r = −0.297; p ≤ 0.001) respectively. Total osteocalcin and undercarboxylated osteocalcin levels of diabetic patients were lower than those of the healthy control subjects. Fasting serum insulin was higher in patients compared to control subjects. Total osteocalcin and undercarboxylated osteocalcin were negatively correlated with Fasting serum insulin and FBS.
Authors and Affiliations
Ogail Yousif Dawod| Department of Physiology, Faculty of Medicine, University of Shandi, Shandi, Sudan, Corresponding e-mail: ogail76@gmail.com, Amar Babikir Elhussein| Department of Biochemistry, Nile College for Medicine and Medical Science, Khartoum, Sudan, Mohamed Abd El-Rahim Ahmed| Department of Physiology, Faculty of Medicine, University of Shandi, Shandi, Sudan, Nour Eldaim Elnoman Elbadawi| Department of Biochemistry, College of Medicine, University of Shaqra, Shaqra, Saudi Arabia, Omer Abdel Aziz Musa| Department of Physiology, Faculty of Medicine, The National Ribat University, Sudan
Keywords
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