Correlation of Osteocalcin Level with Blood Glucose Concentration and Insulin Level in Type II Diabetic Sudanese Patients
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2017, Vol 6, Issue 10
Abstract
Osteocalcin, a bone-derived protein, has recently been reported to affect energy metabolism, this study aimed to evaluate the effects of osteocalcin level on blood glucose concentration and insulin level in type II diabetic Sudanese patients. In this cross-sectional study, one hundred ffteen type II diabetic patients were enrolled in the study (34 males and 81 females) with ages ranging between 18 and 90 years. Total osteocalcin, undercarboxylated osteocalcin, and insulin were measured using ELISA technique. Fasting blood glucose and lipid profle were measured by a spectrophotometer. Mean serum osteocalcin concentration in diabetic patients was signifcantly lower than those in control subjects (p ≤ 0.001). Undercarboxylated osteocalcin in diabetic patients was signifcantly lower than in control subjects (p ≤ 0.001). Fasting insulin was signifcantly higher in diabetic subjects compared to control subjects (p ≤ 0.001). Osteocalcin was negatively correlated with insulin and FBS (r = −0.530; p ≤ 0.001), (r = −0.373; p ≤ 0.001) respectively. Undercarboxylated was negatively correlated with insulin and FBS (r = −0.634; p ≤ 0.001), (r = −0.297; p ≤ 0.001) respectively. Total osteocalcin and undercarboxylated osteocalcin levels of diabetic patients were lower than those of the healthy control subjects. Fasting serum insulin was higher in patients compared to control subjects. Total osteocalcin and undercarboxylated osteocalcin were negatively correlated with Fasting serum insulin and FBS.
Authors and Affiliations
Ogail Yousif Dawod| Department of Physiology, Faculty of Medicine, University of Shandi, Shandi, Sudan, Corresponding e-mail: ogail76@gmail.com, Amar Babikir Elhussein| Department of Biochemistry, Nile College for Medicine and Medical Science, Khartoum, Sudan, Mohamed Abd El-Rahim Ahmed| Department of Physiology, Faculty of Medicine, University of Shandi, Shandi, Sudan, Nour Eldaim Elnoman Elbadawi| Department of Biochemistry, College of Medicine, University of Shaqra, Shaqra, Saudi Arabia, Omer Abdel Aziz Musa| Department of Physiology, Faculty of Medicine, The National Ribat University, Sudan
Keywords
Related Articles
- EP ID EP12471
- DOI -
- Views 331
- Downloads 20
Visiting hour’s policies in Intensive Care Units: Exploring participants’ views
Visiting patients is a positive and effective strategy to help patients and their families to adapt better with stress and crisis of Intensive Care Units. This study designed with the aim of "exploring the perception of...
Effect of Damask Rose Extract on FSH, LH and Testosterone Hormones in Rats
Damask rose is an herbal medicine that increases libido as recommended in traditional medicine. The present study aimed to evaluate the effect of damask rose extract on serum levels of sex hormones in male rats. In this...
REGAUDS TUMOUR INVOLVING THE TONSILS: A CASE REPORT
Regauds tumour is a lymphoepithelioma which usually arises in the nasopharynx. Outside the nasopharynx such lymphoepithelioma like carcinomas are exceedingly rare. Such tumours in the tonsil are rare. Here we report a...
Te Scope of Overweight/Obesity among Medical Participants
Background: Obesity and overweight occurrence in individuals is regarded to be the major concern in numerous countries. The study aimed to understand the scope and identify the factors that could associate with overweig...
Comparison of nursing and midwifery students’ perceptions of the educational environment
Educational environment is an extremely essential part on students’ learning and educational activity. Perception of educational environment influences student learning and educational outcomes. Learning is situated w...