Correlation of Plasma Fibrinogen Level among Diabetic and Non Diabetic Ischemic Stroke Patients
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 7
Abstract
Stroke is defined as rapidly developing clinical signs of focal disturbance of cerebral functions with symptoms lasting for 24hrs or longer or leading to death, with no apparent cause other than vascular origin. Fibrinogen participates in two crucial events in hemostasis. It is an adhesive protein essential for platelet aggregation and platelet plug formation at the site of vascular damage. To compare the plasma fibrinogen level among diabetic and non-diabetic stroke patients. Materials and Methods: The present study was conducted on stroke patients those who are admitted in the Stroke ward of Department of Neurology, SRMC&RI. The sample size was around 36 patients. Among them 20 where diabetic stroke patients and 16 were non diabetic stroke patient’s .The age groups of 36 members were around 45 to85 yrs. Plasma fibrinogen level was estimated by rapid turbid method with standardized reagents. Our results showed there was a marked rise level of plasma fibrinogen among diabetic stroke patients was around 516.5 ± 167mg/dl P value < 0.001.When compared to non-diabetic subjects the value was around 386.8 ± 55mg/dl the P value < 0.001.Which is statically significant. In conclusion the fibrinogen is a factor which is responsible for the non–traditional stroke. The increased fibrinogen level in blood may lead to excessive clumping of blood cells, causing a clot formation in the major artery, which may promote the development early stage of Stroke in old age. From our study we concluded that the serum plasma fibrinogen level is elevated in diabetic stroke patients when compared to non-diabetic stroke patients. Keywords: Atherothrombosis, Cerebral hemorrhage, cerebral thrombosis, cerebrovascular disease, Plasma Fibrinogen, Diabetes mellitus, Stroke
Authors and Affiliations
Anbuselvan V, Shyamala Ramnath, Padmavathi. R, Jayachandran Paulswamy, Velmurugendran CU
Keywords
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