CORRELATION OF PROGNOSIS AND RENAL DYSFUNCTION WITH CLINICAL AND LAB PROFILE IN PLASMA CELL NEOPLASMS
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 72
Abstract
BACKGROUND Plasma cell neoplasms are characterised by clonal proliferation and accumulation of immunoglobulin producing B cells that typically secrete a monoclonal immunoglobulin called M-protein.1 Multiple myeloma is the commonest of the plasma cell neoplasms with an annual incidence of 1% of all malignancies and 10% of all haematological malignancies.2 Indian incidence is approximately 6,000 new cases/year.3 Renal complications develop in 20%-25% of myeloma.4 Various new methods like cytogenetics and serum β2 microglobulin estimation are ideal in measuring the prognosis of myeloma.5 But, these are not available in most institutes. So, this study is done to assess the association of prognosis and renal dysfunction in plasma cell neoplasms based on routine clinical, hematological and biochemical variables. MATERIALS AND METHODS Patients were followed up for a maximum period of 3 years to evaluate the prognosis. Renal dysfunction was measured using serum creatinine and blood urea estimation. Statistical Analysis- The data was analysed with the help of computer software SPSS version 18. RESULTS Fifty seven patients were newly diagnosed with plasma cell neoplasms. Male gender, thrombocytopenia, presence of recurrent infections and hyperphosphatemia were associated with bad prognosis. 28% of the study population had renal involvement at presentation. The factors which showed statistically significant association with renal dysfunction were serum calcium and serum phosphate. CONCLUSION Reasonably good assessment of prognosis and risk of renal failure can be made by evaluating routine parameters like gender, platelet count, serum phosphate, serum calcium and the presence of recurrent infections.
Authors and Affiliations
Ponmaleri Koroth Sangeetha, Saji Francis, Chettithodi Sivasankaran Bindu, Mohamed Shaan
Keywords
Related Articles
- EP ID EP282261
- DOI 10.18410/jebmh/2017/856
- Views 62
- Downloads 0
NON HODGKIN’S LYMPHOMA OF RIGHT TONSIL: A RARE CASE STUDY
Non-Hodgkin’s lymphoma is not one disease but many. It embraces a spectrum from low grade; indolent disease with an untreated natural history which may be measured in decades through to aggressive types which, if untreat...
AGGRESSIVE ANGIOMYXOMA AS A PEDUNCULATED GROWTH OF VULVA: A RARE CASE REPORT
Aggressive Angiomyxoma is a slow growing, uncommon myxoid neoplasm occuring chiefly in the genital, perineal and pelvic regions of adult women.(1,2) It is considered as a nonmetastasizing tumour with locally aggressive n...
STUDY OF PLATELET-TO-LYMPHOCYTE RATIO IN PATIENTS WITH METABOLIC SYNDROME
BACKGROUND Metabolic Syndrome (MS) is considered as a major public health concern since the prevalence has reached epidemic proportions in the past decade. The Platelet-to-Lymphocyte Ratio (PLR) has recently emerged as a...
RETINOPATHY OF PREMATURITY- A CLINICAL STUDY
BACKGROUND The aim of the study is to detect the incidence of retinopathy of prematurity among low birth weight and preterm infants and identification of potential risk factors for retinopathy of prematurity. MATERIALS A...
GENDER SENSITIZATION OF MEDICAL PROFESSIONALS IN THE EXAMINATION AND TREATMENT OF RAPE VICTIMS: A CRITICAL ANALYSIS
Rape is the ultimate crime a man can commit against woman. Rape is the humiliation of a woman‟s body and soul. It is the subordination of women by men in a patriarchal society. It is the violation of a woman‟s right to l...