Correlation of RUNX3 expression with microvessel density in colorectal adenocarcinoma tissues and clinical significance
Journal Title: Asian Pacific Journal of Tropical Medicine - Year 2017, Vol 10, Issue 1
Abstract
Objective: To study the expression of RUNX3 in colorectal adenocarcinoma tissues and its correlation with microvessel density (MVD), and investigate the clinical pathological prognostic significance of RUNX3 and MVD in patients with colorectal cancer. Methods: The expression value of RUNX3 and MVD in 70 specimens’ colorectal adenocarcinoma tissues were detected by immunohistochemistry staining technique. The correlation between their expression and the clinicopathologic features was also investigated. Results: The expression value of RUNX3 and the positive rates of RUNX3 in colorectal adenocarcinoma tissues were 3.25 ± 1.14 and 25.71% (18/70). The expression value of MVD in colorectal adenocarcinoma tissues was 13.14 ± 3.23. Expression of RUNX3 and MVD value were correlated with CEA, serosal invasion, liver metastasis, lymph node metastasis, and TNM stage (P < 0.01). The expression value of RUNX3 had negative correlations with that of MVD. Conclusions: The high expression of RUNX3 could inhibit tumor microvascular generation in order to have negative control response on invasion and distant metastasis.
Authors and Affiliations
Jun Xue
Keywords
Related Articles
- EP ID EP278436
- DOI 10.1016/j.apjtm.2016.11.010
- Views 92
- Downloads 0
Chemical analysis and in vitro antimicrobial effects and mechanism of action of Trachyspermum copticum essential oil against Escherichia coli
Objective: To find a natural plant essential oil (EO) with excellent antimicrobial effects on food-borne bacteria and to explore the mechanism of its antimicrobial function against Escherichia coli (E. coli). Methods: Th...
Clinical study inpatient-reported outcomes after binocular implantation of aspheric intraocular lens of different negative spherical aberrations
Objective: To compare patient-reported outcomes after implantation of the ZA9003 intraocular lens (IOLs), or the MCX11 ASP IOLs or the spherical IOLs (HQ-201HEP). Methods: Prospective nonrandomized controlled trial was u...
Wild chive oil is an extremely effective larvicide against malaria mosquito vector Anopheles stephensi
Objective: To assess the chemical composition and mosquito larvicidal potentials of essential oil of wild chive (Allium schoenoprasum L.) against Anopheles stephensi. Methods: In the search for an environmentally safer...
Molecular and serological prevalence of Toxoplasma gondii in pregnant women and sheep in Egypt
Objective To investigate molecular and serological prevalence of Toxoplasma gondii (T. gondii) in pregnant women and sheep in Egypt. Methods Blood samples collected from healthy 364 pregnant women and 170 sheep were in...
Zika virus infection and its emerging trends in Southeast Asia
Zika virus is a mosquito-borne flavivirus that represents a public health emergency at the ongoing epidemic. Previously, this rare virus was limited to sporadic cases in Africa and Asia until its emergence in Brazil, Sou...