CORRELATION OF SERIC BIOMARKERS AND CELLULAR ELEMENTS IN SPUTUM AND BLOOD, IN RELATION TO THE GRAVITY OF COPD
Journal Title: International journal of ecosystems and ecology science (IJEES) - Year 2017, Vol 7, Issue 1
Abstract
Research in relation to the biomarkers to define exacerbation, gravity and it’s progress in COPD has been made and continued to be made. By present literature, it result that biomarkers correlate with clinical gravity, with the time of the recovery period, persistence of symptoms and clinical resolution, with exacerbation frequency. Aim: The study has as an aim, the evaluation of the correlation of seric biomarkers and cellular elements in sputum, and blood in relation to the gravity of COPD. Method: The abstract is an observing prospective study conducted on the Regional Hospital “Fier”. In the study, patients presented with exacerbated COPD of stages III and IV were considered. Based on a protocol, in patients with COPD exacerbations, anamnestic data as well as data from clinical and laboratoric examinations was collected. It has been defined in the time of introduction for the reason of COPD exacerbations and after 21 days, CRP, IL6, PARC/CCL18, cellular content of sputum and blood. The statistical analysis was conducted through SPSS (Statistical Package for Social Sciences) 20.0 and Medstat. Values of p ≤0.05 were considered significant. Results: In the patient with COPD exacerbations of stages III and IV, significant changes of cellular elements in blood and sputum were observed. In relation to the values of the original CRP in normal boundaries there is no case in the D4 category and value higher than the level from 40 to 200 mg/l are in relation to categories D3 and D4. In the examination of IL6 in exacerbation, it can be observed that cases with a level >7 pg/ml are grouped in categories D3 and D4; PARC in values >30ng/ml are 91.1% of cases, whereas in values >60 ng/ml are in 66.1% of cases. The greatest number of cases PARC in the values >30ng/ml, as well as for values >ng/ml, are in categories D3 and D4. According to the data of the correlations analysis, it results that original CRP correlated in a significant manner with COPD stage (p=0.005); IL6 (p=0.038). PARC (p=0.054). Conclusions: It results that there are significant changes in stages III and IV in relation to the stage of inflammation based on cellular structure in sputum, number and cellular elements of blood and the levels of CRP, IL6 and PARC/CCL18 in blood.
Authors and Affiliations
Juliana Gjerazi1, Eritjan Tashi2, Ervis Rapaj1, Irma Tashi3, Regina Hasa2, Teuta Feleqi1, Jul Bushati2, Perlat Kapisyzi2
Keywords
Related Articles
- EP ID EP278406
- DOI -
- Views 84
- Downloads 0
ANALYSIS OF THE EFFECTS OF CERTAIN EXOTIC ORNAMENTAL PLANTS ON SOIL PROPERTIES: THE KARADENIZ TECHNICAL UNIVERSITY CAMPUS CASE
The use of increasingly diverse exotic ornamental plants in urban open green spaces has led to more heterogeneous urban landscapes. The studies on ecological effects of these plants on the existing soil properties and on...
ANTIPSYCHOTIC TREATMENT AND METABOLIC ALTERATION IN PATIENTS WITH SCHIZOPHRENIA
Psychopharmacology has become more complex over the past decade or so, with many more medications available from different pharmacologic classes. To investigate the alterations of biochemical parameters, in patients with...
LABORATORY, SOCIETY, TRAUMA “VECTORS” (CONSEQUENCES), PARTS OF NON-EUCLIDEAN TRIANGLES
Introduction: Traumatic experience is not only physical and psychological, but and social. Social, psychological and physical traumas are communicative vessels that have a significant impact on each other, so the medical...
THE EVALUATION OF THE ENERGY EFFICIENCY OF DAIRY FARMS WITH FREESTALL AND LOOSE HOUSES IN KONYA SUGAR INDUSTRY AND TRADE INC., TURKEY
Energy use is indispensable for sustainable agricultural production. Determination of energy use efficiency is pivotal for the productivity of dairy farms. In recent years, the Konya Region has the highest milk productio...
ORGANIC CULTIVATION OF MAKHANA IN LOW LAND DURING RAINY SEASON FOR ENHANCING FARM PROFITABILITY
Proper agronomic practices are needed to harness the maximum benefit of genetic potentials of crop and nutrient availability in any production system. Thus, in the current study, wecompared different methods of makhana o...