Correlation of serum C-reactive protein in painful vaso-occlusive crisis in sickle cell disease and its response to analgesic therapy
Journal Title: International Archives of Integrated Medicine - Year 2018, Vol 5, Issue 2
Abstract
Background: Sickle cell disease is characterized by chronic hemolysis, frequent infections and recurrent occlusions of microcirculations, which causes painful crisis and results in chronic organ damage and failure. Occlusion of microcirculation and infection are important factors that stimulates production of cytokines and acute phase proteins like C- reactive protein. Aim: To estimate serum C-reactive protein levels in cases of painful vaso-occlusive crisis of sickle cell disease, to study correlation of level of serum C-reactive protein with duration of painful vaso-occlusive crisis of sickle cell disease, to study relation between level of serum C-reactive protein and treatment response of analgesic versus analgesic opioid in cases of painful vaso-occlusive crisis of sickle cell disease. Materials and methods: This hospital based observational case control study was carried out at IGGMC, Nagpur, Maharashtra, India. Total 31 cases of sickle cell vaso-occlusive crisis, of age 12 years and above, admitted in hospital and 31 controls included in study. Study protocol was followed in each case. Results: Musculoskeletal, joint pain (83.87%) was most common form of presentation. Exhaustion and severe physical activity (25.80%) was most common precipitating factor. Mean hemoglobin, bilirubin showed statistically significant difference in cases compared to control. Mean CRP on day 1 (40.87±17.22 mg/L) was significantly high compared to control (3.67±0.77 mg/L) with statistical significance p<0.0001. Conclusion: Serum C- reactive protein levels are higher in cases of painful sickle cell vaso-occlusive crisis than control. C- reactive protein levels correlate positively with duration of pain in cases of painful sickle cell VOC. Steady state C- reactive protein level is normal in cases of sickle cell anemia. Cases of painful sickle cell VOC in whom opioid had to be used in addition to NSAIDs for pain management had higher CRP levels than who responded to NSAIDs alone. The cases in whom serum C- reactive protein levels were >33.2mg/L required use of opioid for pain management of sickle cell VOC. However, sample size of the present study is small and will need further prospective study.
Authors and Affiliations
Shweta P. Bijwe, Mithil B. Ghushe
Keywords
Related Articles
- EP ID EP413564
- DOI -
- Views 90
- Downloads 0
Evaluation of fracture resistance of mandibular incisors before and after endodontic treatment and metal ceramic crown placement
Background: Mandibular incisors are the smallest among the permanent dentition, with thin enamel and dentin. Intact teeth do not fracture easily while mastication. Objectives: To evaluate the fracture resistance of mandi...
A study on the association of socio-demographic factors and secondary infertility among mothers with unmet needs of family planning in Sangareddy
Background: The concept that eventually became unmet need of family planning was explored in 1960 when data from surveys of contraceptive KAP shoed a gap between some women’s reproductive intention and their contraceptiv...
Prevalence and biochemical profile of subclinical hypothyroidism among female patients attending OPD of a teaching hospital in Bihar: A hospital based observational study
Background: Hypothyroidism is one of the leading endocrine problems worldwide. Prevalence of high rates of subclinical hypothyroidism has been found in hilly areas. It leads increased risk of cardiovascular diseases, dys...
Dentistry as a career: Factors and Motivational Reasons - A Comparative questionnaire study of Students of Public and Private Schools in Saudi Arabia
Background: Many studies have been done to find out the motivational factors in choosing dentistry as a career. Only few studies are carried in middle East countries like Saudi Arabia. Aims and Objectives: To establish t...
Spectrum of salivary gland tumors - A five year study
Introduction: Salivary gland tumors are common neoplasms of head and neck region. These tumors are complex and exhibit great clinicopathological variation which may show racial and geographical differences. Aim: The aim...