Correlation of serum hyaluronic acid with clinical and radiological severity in primary knee osteoarthritis
Journal Title: International Journal of Orthopaedics Sciences - Year 2018, Vol 4, Issue 2
Abstract
Objective: To investigate relationship between serum hyaluronic acid (sHA) level and the presence and severity of radiographic knee osteoarthritis (OA) as well as degree of knee pain. Design: A total of 150 subjects (75 controls and 75 cases) were enrolled in this study. Based on the Kellgrene Lawrence (K-L) grade, participants were radiographically classified into three groups: mild (K-L grade1 & 2), moderate ( K-L grade 3) and severe (K-L grade 4). The degree of knee pain was quantified by WOMAC knee pain score. sHA levels were compared among the controls & cases and with radiological grading. In addition, the correlation between sHA level and the degree of knee pain was analyzed in each group. Results: In relationship between sHA level and the severity of radiographic knee OA, sHA level of the case group was significantly higher than in the normal group (P< 0.001). Furthermore, sHA level correlated with the severity of radiographic knee OA (r = 0.880). sHA level had positive correlation and significant association with WOMAC knee pain in study groups. (r = 0.750, P<0.001). Conclusion: sHA level has the potential to be useful for the diagnosis and prognosis of the severity of primary knee OA.
Authors and Affiliations
Dr. Vishnu Mittal, Dr. Anurag Chhabra, Dr. Ashok Kumar, Dr Swaranjeet Soni, Dr. Surender Singh, Dr. Yogesh Aggarwal
Keywords
Related Articles
- EP ID EP486768
- DOI 10.22271/ortho.2018.v4.i2g.64
- Views 116
- Downloads 0
A prospective study to evaluate the functional outcome of sub-trochanteric femur fractures with long proximal femoral nail
Introduction: Sub-trochanteric fractures of the femur remains one of the most challenging fractures faced by orthopaedic surgeons. This study was done to analyse the functional outcome of management and complications of...
Comparison of radiological outcome of unstable Intertrochanteric femur fractures in elderly patients treated with Indian and Foreign Cephalomedullary nails
Aim of study: Purpose of study was to compare the radiological outcome of unstable intertrochanteric fractures in the patients treated by Indian and Foreign Cephalomedullary nails. Methods: 417 patients aged 65 years and...
Surgical management of distal tibia fracture by mippo using locking compression plate
Introduction: The following study was conducted to examine the short term clinical and radiological results particularly early complications and healing rate of distal tibia fracture treated by MIPPO using LCP. Methodolo...
Does accelerated bone healing associated with traumatic brain injury (TBI) occur in open fractures
Aim: Accelerated bone healing has been frequently reported in patients with traumatic brain injury (TBI). However, all these reports are restricted to closed fractures and there is no literature of the effect of TBI in o...
An unusual presentation of tubercular dactylitis with subluxation of the metacarpo-phalangeal joint in an adult
Introduction: Tuberculosis rarely affects the bones of the hand and feet. This entity is described as tubercular dactylitis (TB dactylitis). It affects children. TB dactylitis in an otherwise healthy adult is extremely r...