Correlation of Serum Leptin Levels With the Disease Activity in Rheumatoid Arthritis Patients
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 8
Abstract
Abstract:Rheumatoid Arthritis is an autoimmune disease affecting 0.5-1% of general population. Among the adipokines secreted by the adipocytes, Leptin act as a new mediator of the inflammatory process and plays a major role in the pathogenesis of Rheumatoid Arthritis. Serum Leptin levels was determined and correlated with the disease activity in the Rheumatoid arthritis patients.60 Rheumatoid arthritis patients diagnosed by American College of Rheumatology (ACR) criteria 2010 aged 25-55years were included in the study. Serum Leptin levels, Erythrocyte sedimentation rate (ESR) were studied and the disease severity calculated and categorised. The mean serum Leptin concentration in RA patients with high disease activity (n=26) was more (51.32+ 33.81ng/mL) than that in moderate activity (n=34) (46.83+30.92ng/mL), though the difference in the mean between the two groups was not statistically significant. As the serum Leptin levels were significantly higher in the RA patients than in the controls it is understood that Leptin plays a pivotal role in the pathogenesis of RA as a proinflammatory cytokine. However no correlation was observed between serum Leptin levels and disease activity of the RA patients. Keywords:Rheumatoid Factor, Leptin, Polyarthritis, Disease activity Score, ESR, Obesity, Inflammation, ACR criteria
Authors and Affiliations
Michael RajamGeetha, V. G. Karpaghavalli, J. Siva Somana
Ocular globe Rupture following Forceps assisted-delivery
Forceps assisted delivery can cause serious eye damage to the neonates. In some cases it can even cause the loss of the eyeball with a subsequent blindness. We report a case of a neonate who lost his eye during a prolong...
Metastatic Seminoma Presenting As Enlarged Neck Node: Diagnosis by Fine Needle Aspiration Cytology
In testicular malignancy, the incidence of neck metastases range from 4.5 to 15% and in an estimated 5% of these cases, a neck mass is the initial presentation. We present a case of testicular seminoma which presented wi...
A Study of Diaphyseal Fractures of Forearm Bones with Nailing and Plating
Abstract: Anatomical reduction and internal fixation of forearm fractures can facilitate restoration of function. Any axial or rotatory malalignment or any narrowing of interosseous space produces disproportionate loss o...
Efficacy of Non Invasive Ventilation in Patients of Respiratory Failure: Study of 50 Patients
Non-invasive ventilation has been shown to be an effective in the mangement of acute hypercapnic respiratory failure, particularly in chronic obstructive pulmonary disease (COPD). The priority of non-invasive ventilation...
Ivabradine: A Novel Drug to Control Heart of Patients Undergoing CT Coronary Angiography
Heart rate control is crucial for diagnostic accuracy and proper image quality of CTCA. A lower heart rate reduces coronary artery movement artifacts by increasing the length of diastolic phase, thereby improving image q...