Correlation of serum PSA level with histomorphologic study in prostatic diseases
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 4
Abstract
Introduction Worldwide diseases of prostate gland are responsible for significant morbidity and mortality among adult males Prostate cancer is the second common cause of cancer related death in men after lung cancer but it can be completely cured if detected in early stageAim To evaluate the histomorphological spectrum of nonneoplastic and neoplastic lesions of prostate and to establish the correlation of histomorphological findings with serum prostate specific antigens levelsMaterials and Methods 1 year Prospective Study was done on 110 patient at Department of Pathology Indira Gandhi Medical College Shimla HP from 1st July 14 to 30th June 15 Unwilling patient inadequate biopsies and patient with metastatic carcinoma to prostate were excluded from study Paraffin embedded sections were stained with routine haematoxylin and eosin stain The PSA levels were estimated in biochemistry department using automated Chemiluminescence method on Beckman Coulter Access II System These values were correlated with histopathological diagnosisResult With 633 benign prostatic hyperplasia was the most common lesion followed by Malignancy in 291 and prostatic intraepithelial neoplasia in 73 of total cases Serum prostate specific antigens level was increased in 655 cases Mean serum prostate specific antigens value of benign prostatic hyperplasia with and without inflammation is and109ngml and98ngml respectively Mean serum prostate specific antigens value is 189 ngml in Low Grade and785 ngml in high grade prostatic intraepithelial neoplasm Mean serum prostate specific antigen in malignancy was 1012ngml antigen inConclusion On statistical analysis PSA is found to be a sensitive and early marker for the diagnosis of prostate cancer With a cut off value of 4ngml sensitivity was found to be 9375 and specificity was 4615 Keywords Adenocarcinoma prostate Benign prostatic hyperplasia Prostatic intraepithelial neoplasia Prostatitis Serum prostate specific antigens
Authors and Affiliations
Neelam Sharma, Kavita Kumari, Sudershan Kumar Sharma, Saroj Jaswal, Kailash Barwal
Keywords
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- EP ID EP475932
- DOI 10.18231/2394-6792.2018.0117
- Views 83
- Downloads 0
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