Correlation of serum thyroid stimulating hormone and prolactin in female infertility � a case control study
Journal Title: Indian Journal of Obstetrics and Gynecology Research - Year 2016, Vol 3, Issue 4
Abstract
Background: Thyroid dysfunction and high prolactin levels can affect fertility due to anovulatory cycles, luteal phase defects and sex hormone imbalance. The study was designed to evaluate the status of Thyroid stimulating hormone (TSH) and prolactin in female infertility after exclusion of tubal factor and male factor infertility, and to determine the degree of association of TSH with prolactin in cases of infertility. Material & Methods: The study design was a randomized case control study conducted at Rohilkhand Medical College & Hospital, Bareilly, U.P. The study subjects included 50 infertile and 50 normal fertile women in the age group of 20- 40 years attending Gynaecology OPD during one year study period. The TSH and prolactin hormones were assayed using Enhanced Chemiluminescence Immunoassay and Enzyme Linked Immunosorbent Assay. Student’s t-test, Analysis of variance and Pearson’s correlation were used to analyze the data, with the significant p-level set at <0.05. Results: We found significantly higher mean TSH and prolactin levels in infertile females when compared with the normal fertile females. The mean TSH values were significantly higher in both primary and secondary infertility cases whereas mean prolactin level was significantly increased in primary infertility cases only. TSH and prolactin levels showed significant positive correlation in both primary and secondary infertility cases. Conclusion: There is a greater propensity for thyroid dysfunction and a higher prevalence of hyperprolactinemia in infertile women than the fertile ones and therefore, estimation of thyroid profile and prolactin should be included in the workup for infertile women.
Authors and Affiliations
Shikha Saxena, Ranjana Gupta, Lata Agarwal, Prem Chandra Srivastava, Ayaz Khurram Mallick
Keywords
Related Articles
- EP ID EP242066
- DOI -
- Views 100
- Downloads 0
Outcome of immediate postpartum insertion of IUCD - A prospective study
Introduction Immediate postpartum intrauterine contraceptive device insertion is an excellent family planning method which provided safe effective long term and reversible contraception to women in the delivery setting H...
Management of missing threads of IUCD
Introduction: Intra uterine contraceptive device is an effective, reversible and long term method of contraception. The device is made of poly ethylene which is impregnated with barium sulphate to render it radio opaque...
Study of Cutaneous manifestation of pregnancy in a Tertiary Care Hospital, South India
Background: Pregnancy is a period of profound immunologic, endocrine, metabolic and vascular changes, which makes them venerable for physiological and pathological changes in skin and its appendages. Dermatoses unique to...
Comparative study of immediate post placantal versus interval IUCD (CuT 380A Insertion)
Introduction Unintended pregnancy is still a major concern in India It can be only prevented by effective contraceptive measures especially if it is used in postpartum period as it is highly vulnerable period to unintend...
Impact of socioeconomic and demographic factors on reproductive tract infections during reproductive age group (18-45) years
Introduction The Aims of this study were to identify the prevalence of reproductive tract infection in married women of reproductive age group 1845 years to analyse the impact of socioeconomic and demographic factors on...