Correlation of serum thyroid stimulating hormone and prolactin in female infertility � a case control study
Journal Title: Indian Journal of Obstetrics and Gynecology Research - Year 2016, Vol 3, Issue 4
Abstract
Background: Thyroid dysfunction and high prolactin levels can affect fertility due to anovulatory cycles, luteal phase defects and sex hormone imbalance. The study was designed to evaluate the status of Thyroid stimulating hormone (TSH) and prolactin in female infertility after exclusion of tubal factor and male factor infertility, and to determine the degree of association of TSH with prolactin in cases of infertility. Material & Methods: The study design was a randomized case control study conducted at Rohilkhand Medical College & Hospital, Bareilly, U.P. The study subjects included 50 infertile and 50 normal fertile women in the age group of 20- 40 years attending Gynaecology OPD during one year study period. The TSH and prolactin hormones were assayed using Enhanced Chemiluminescence Immunoassay and Enzyme Linked Immunosorbent Assay. Student’s t-test, Analysis of variance and Pearson’s correlation were used to analyze the data, with the significant p-level set at <0.05. Results: We found significantly higher mean TSH and prolactin levels in infertile females when compared with the normal fertile females. The mean TSH values were significantly higher in both primary and secondary infertility cases whereas mean prolactin level was significantly increased in primary infertility cases only. TSH and prolactin levels showed significant positive correlation in both primary and secondary infertility cases. Conclusion: There is a greater propensity for thyroid dysfunction and a higher prevalence of hyperprolactinemia in infertile women than the fertile ones and therefore, estimation of thyroid profile and prolactin should be included in the workup for infertile women.
Authors and Affiliations
Shikha Saxena, Ranjana Gupta, Lata Agarwal, Prem Chandra Srivastava, Ayaz Khurram Mallick
Keywords
Related Articles
- EP ID EP242066
- DOI -
- Views 86
- Downloads 0
Case series: Association of cervical lymphoepithelioma-like carcinoma with HPV-16
Lymphoepithelioma-like carcinoma of the cervix is a variant of squamous cell carcinoma. Of all cervical cancer it comprises about 0.7% cases. It differs from the usual squamous cell carcinoma of cervix in its clinical be...
Impact of laparoscopic ovarian drilling on anti-mullerian hormone levels in women with clomiphene resistant polycystic ovary syndrome
Introduction: Patients with PCOS not only have raised androgen levels which leads to anovulation but may also have high AMH levels. When ovulation induction fails, androgen levels are reduced by laparoscopic ovarian dril...
Fallopian Tube Prolapse- A Rare Complication of Hysterectomy
Fallopian tube prolapse is a rare complication of hysterectomy and can be easily mistaken as vaginal granulation tissue or vaginal adenocarcinoma. We are presenting a case of post vaginal hysterectomy fallopian tube prol...
A Comparative study of the etiology of symptomatic vaginal discharge based on WHO syndromic diagnosis and microbiological diagnosis
Introduction Vaginal discharge is the most common complaint with which women of reproductive age group present to the gynecological outpatient WHO syndromic approach algorithm helps in identifying the etiology based on t...
Bacterial vaginosis – a risk factor for preterm labour: a case-control study
Aim: To estimate the prevalence of bacterial vaginosis in preterm labour patients when compared to term labour patients. Materials and Method: It was a hospital based prospective case-control study conducted over a perio...