Correlation of Transfusion Transmitted Infection, Liver Function Test and Serum Ferritin with Multiple Blood Transfused Thalassemic Patients at Tertiary Health Care Centre
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2019, Vol 8, Issue 3
Abstract
Background: Thalassemia is one of the major hemoglobinopathies among the population all around the world. Beta thalassemia major results in severe anemia which needs regular repeated blood transfusion, which leads to iron over load in the body which damages the liver, kidney and other. HIV, Hepatitis B and Hepatitis C are common among multiple blood transfusion patients. So to know the severity of the patient, we retrospectively & prospectively correlated transfusion transmitted infection, liver function test and serum ferritin with multiple blood transfused thalassemic patients. Methods: Total 200 subjects were studied. We examined all patients who are clinically and Hematological suspicion of thalassemia and patients diagnosed to have halassemia based on High Performance Liquid Chromatography (HPLC) over a period of 2 years 3 months. The patients groups were evaluated according to the clinicohematological presentation and HPLC study. Results: Mean value of serum ferritin in thalassemia major group was found to be significantly increased (4103.21 ± 2786.9 ng/ml). In thalassemia major group, out of 78 cases 4 cases found reactive for HBV and 9 cases found reactive for HCV. Conclusion: There is significantly higher seroprevalence of both hepatitis B and C markers was observed among the multi-transfused thalassaemic children. Blood screening has significantly reduced the risk of transfusion related hepatitis B and C. However, the risk is still there. So, the health care providers who are involved in the management and blood transfusion of thalassaemic patients should be more aware of this problem.
Authors and Affiliations
Shankar Marshal Toppo
Keywords
Related Articles
- EP ID EP595182
- DOI 10.21088/ijprp.2278.148X.8319.8
- Views 67
- Downloads 0
Morphological Spectrum of Endometrium in Dysfunctional Uterine Bleeding
Introduction: Dysfunctional uterine bleeding (DUB) is defined as increased abnormal endometrial bleeding unrelated to any anatomic lesions/ organic pathology of the genital tract [1]. It is a common problem in woman of r...
Histomorphological Study of Ovarian Tumors : A Three Year Institutional Experience
Context: Ovary contains four major types of tissue (Surface epithelium, Germ cells, Sex cords and Ovarian stroma), all of which can give rise to a variety of neoplasms, often combined with a varied morphological and hist...
Respiratory Epithelial Adenomatoid Hamartoma: An Under-Reported Pathological Entity
Respiratory epithelial adenomatoid hamartomas (REAHs) are rare, benign proliferations of glands of respiratory tract. These are under diagnosed and pose a challenge while diagnosing other aggressive lesions. We are prese...
Study of Mast Cells in Different Pathological Conditions of Surgically Resected Appendix
Mast cells arise from the hemopoietic progenitor cells of the bone marrow derived and were first discovered by Paul Ehrlich in 18th century. They are found in varying numbers in different tissues and are abundant near bl...
Recommendation for Modification in the Bethesda System for Reporting of Thyroid Cytopathology: A Study in a Tertiary Care Hospital
Introduction: Thyroid is the endocrine organ situated in the midline of the neck.Its pathology varies from nutritional disorders like multinodular goiter to high grade malignancy like anaplastic carcinoma. Since the thyr...