Correlation Of Viral And Bacterial Concentrations In Plaque And Glycemic Status In Patients With Chronic Periodontitis With And Without Type 2 Diabetes Following Phase 1 Therapy - A Clinical, Microbiological And Biochemical Assessment.
Journal Title: International Journal of Dental Science and Innovative Research (IJDSIR) - Year 2019, Vol 2, Issue 2
Abstract
Background & Objectives: With increasing evidences implicating the role of viruses in periodontal disease and diabetes, the present study aimed to assess, compare and correlate the change in clinical periodontal parameters; viral and bacterial pathogen concentrations in plaque and Glycated hemoglobin levels (HbA1c) in patients with chronic periodontitis with and without type 2 diabetes. Method :120 patients with chronic periodontitis (mild to moderate) were divided into two main groups as Group 1 (control n=30 non-diabetic patients) and Group 2(test n= 90 patients with type 2 diabetes) which were further subdivided based on glycemic control. Clinical parameters viz gingival index, plaque index, probing pocket depth & relative attachment level; and HbA1c levels were evaluated at baseline,1 and 4 months following phase -1 therapy, along with microbiological parameters viz bacteria (Pg,Pi,Tf,A.a) and viruses (HSV,EBV,HCMV) in the plaque samples by PCR analysis. Results: Significant improvements in clinical and microbiologic parameters and HbA1c levels (p˂0.05) were observed within all groups with more significant clinical changes in group 1(control) compared to the (test) groups following phase 1 therapy. Viruses were not detected in most of the samples tested. Significant positive correlation of clinical parameters with bacterial counts(p<0.05) but not with the viral counts, and specifically probing depths with HbA1c levels in the diabetic group (p<0.05), were observed. Conclusion: Although phase-1 therapy resulted in enhancement of clinical parameters, glycemic status and reduction in bacterial counts, the role of viruses in periodontal disease seems questionable as the proportion detected was negligible.
Authors and Affiliations
Dr Shreya Shetty
Keywords
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