Correlation study between body mass index, body fat, glycemic indices and lipid profile with insulin resistence and secretion in healthy euthyroid individuals
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2018, Vol 5, Issue 1
Abstract
Introduction: Insulin resistance and secretion are highly dependent on variable influencing factors, in the developmental process of Diabetes mellitus. Growing incidence of diabetes prompt us to study the various contributing factors in the development of Diabetes mellitus in healthy individuals. Objective: To study the relationship associated between anthropometric measurements, plasma lipids, glycemic indices, thyroid stimulating hormone with Insulin resistance and secretion in healthy individuals. Materials and Methods: A cross-sectional study was conducted in normal healthy individuals, from general population.(n=142).Body mass index, body fat, were measured, Glycemic indices, fasting glucose, post prondial glucose, Glycated hemoglobin, fasting insulin levels, Thyroid stimulating hormone, fasting lipid profile were analysed. Result: Insulin resistance (HOMA IR) is positively correlated with Glycemic indices (FBS, PPBG, HbA1C) P<0.05, Body mass index P<0.05, Body fat P<0.05, and Cholesterol/HDL ratio. Serum Thyroid Stimulating Hormone (TSH) P<0.05 is negatively associated with Insulin Secretion. Glycemic Indices, Triacylglycerol, cholesterol, LDL are negatively correlated with Insulin Secretion. Conclusions: Glycemic indices, body mass index, body fat and lipid profile are intrinsically related to Insulin resistance and Insulin secretion. Increased TSH is associated with decreased insulin secretion leading to increase blood glucose levels, which indicates that thyroid hormone is important for pro insulin expression and translation, providing the evidence that, effects of thyroid hormones on carbohydrate metabolism also include the control of proinsulin gene expression, the possible role of thyroid hormones on insulin secretion.
Authors and Affiliations
Mohammad Ibrahim Shaik, Mohammad Siddique Ahmed Khan
Keywords
Related Articles
- EP ID EP472102
- DOI 10.18231/2394-6377.2018.0020
- Views 54
- Downloads 0
Investigating pre and post-operative blood gases and serum electrolyte in patients undergoing coronary artery bypass surgery (CABG)
Background: Arterial blood gas analysis is a common investigation exercised in emergency room and ICU. In post-operative CABG patients, acid base alterations is the commonest problem encountered. Thus, constant check on...
Effect of Chemotherapy on Tumor Marker (Ca 15.3) and Serum in Breast Cancer Patients of Southern Eastern Region of Chhattisgarh; 6 Years Follow up Study
Background: At many centers tumor markers are used to detect disease recurrence and to monitor response to chemotherapy therapy in patients with advanced disease, although the real value of serial observation of marker l...
Correlation study between body mass index, body fat, glycemic indices and lipid profile with insulin resistence and secretion in healthy euthyroid individuals
Introduction: Insulin resistance and secretion are highly dependent on variable influencing factors, in the developmental process of Diabetes mellitus. Growing incidence of diabetes prompt us to study the various contrib...
A case control study of stress and infertility in hypothyroid reproductive age group women residing in Udaipur, Rajasthan, India
Introduction: Challenges to human being fertility may occur from numerous conditions caused through hereditary abnormalities, communicable or else environmental agents, as well as certain behaviors. Reproduction is one o...
Role of serum lipoprotein (a) in type 2 diabetes mellitus and its association with glycemic control
Diabetes mellitus DM is an established risk factor for cardiovascular disease At present global risk assessment lipid profile is only the blood test routinely recommended most commonly Increased lipoprotein a Lpa contrib...