Correspondence between OCT Characteristics and Biochemical Parameters in Diabetic Macular Edema
Journal Title: Iranian journal of diabetes and obesity (IJDO) - Year 2024, Vol 16, Issue 4
Abstract
Objective: The purpose of this study is to evaluate the potential association between peripheral blood parameters and the morphological characteristics of retinal imaging obtained via spectral-domain optical coherence tomography (SD-OCT) in patients with treatment-naïve diabetic macular edema (DME). Materials and Methods: This cross-sectional study included 100 patients with treatment-naïve DME. All participants underwent spectral-domain optical coherence tomography (Optovue) and fundus photography. Peripheral blood samples were collected to assess complete blood count (CBC), glycated hemoglobin (HbA1c), blood glucose, serum urea, serum creatinine, and lipid profile. Results: Central subfield thickness (CST) was significantly associated with serum HDL (P= 0.003). Intraretinal fluid (IRF) was linked to serum triglycerides (P=0.006), serum VLDL (P=0.001), and cholesterol-to-HDL ratio (P= 0.001). Subretinal fluid (SRF) showed an association with blood glucose (P= 0.028). Hyperreflective foci (HF) were related to total blood count (P= 0.001), monocyte count (P= 0.001), cholesterol-to-HDL ratio (P= 0.045), LDL-to-HDL ratio (P= 0.003), and serum urea (P= 0.051). Disorganization of the retinal inner layers (DRIL) correlated with total blood count (P=0.047), lymphocyte count (P= 0.008), blood glucose (P= 0.007), and LDL-to-HDL ratio (P= 0.046). Epiretinal membrane (ERM) was associated with blood glucose (P= 0.001), total cholesterol (P= 0.022), serum LDL (P= 0.025), cholesterol-to-HDL ratio (P= 0.013), and LDL-to-HDL ratio (P= 0.008). Ellipsoid zone (EZ) and external limiting membrane (ELM) disruptions were linked to blood glucose, serum LDL, and VLDL. Hard exudates correlated with blood cell counts, glucose, HbA1c, urea, and creatinine (P< 0.05). CONCLUSION: Systemic factors are significantly associated with retinal morphological patterns in DME, highlighting the potential for modifying these factors to influence disease progression and treatment response.
Authors and Affiliations
Sree Vaishnavi Omprakash,Sangeetha Sekaran,Nivean Madhivanan,Pratheeba Devi Nivean,Lavanya Sambanthan,
Keywords
Related Articles
- EP ID EP760237
- DOI -
- Views 5
- Downloads 0
Association of ABO ,Rh Blood Groups with the Susceptibility of Gestational Diabetes in the Yazd-Iran Population
Objective: Today, the association of blood groups as genetic traits has been confirmed in many diseases. However, its association with gestational diabetes mellitus (GDM) has not been investigated. Therefore, in this stu...
The Antiglycation Ability of Typical Medicinal Plants, Natural and Synthetic Compounds: A Review
Given the prevalence of diabetes and the increasing number of diabetics, it is essential to find medicines to decrease the chronic complications of diabetes. Several studies have demonstrated that chronic hyperglycemia a...
Insulin Edema in Type 2 Diabetes Mellitus: A Case Report Study
Edema is a rare complication induced by insulin therapy, which is mostly developed after initiation or intensification of insulin treatment in diabetic patients. Edema can either be localized or generalized. Our patient...
A Review of Clinical Trial Studies on Medicinal Plants in the Treatment of Diabetes
Objective: The use of medicinal plants in diabetic patients is rising, it is essential to increase knowledge about the effects of medicinal plants and subsequently perform evidence-based action, so, review studies are a...
Diabetic Foot Risk Factors & level in Diabetes People: A Cross-Sectional Study
Objective: Determining diabetic foot risk levels and risk factors and treating foot problems is one of the main components of the prevention of diabetic foot ulcers (DFU). This study aimed to determine diabetic foot risk...