Cost-benefit analysis of hepatitis B virus serological and nucleic acid testing in blood donors
Journal Title: Chinese Journal of Blood Transfusion - Year 2023, Vol 36, Issue 1
Abstract
Objective In an effort to prevent transfusion-transmitted hepatitis B infection, universal HBsAg screening, HBsAg+ MP nucleic acid test(NAT) for HBV and HBsAg + individual(ID) NAT were analyzed for cost-effectiveness. Methods On the basis of screening data and the documented parameter, the number of window period infections, chronic infections and occult infections was constructed, and cost-benefit analysis was conducted. Results Of 132 208 donations, the yield rate of ID NAT for HBsAg-/DNA+ (0.11%) was significantly higher than HBsAg+ MP NAT(0.058%). Furthermore, the predicted preventing transfusion transmitted HBV cases by ID NAT is 1.25 times as that by MP-6 NAT, so did the benefits. The cost-benefit of the three screening models were 1∶63.6、1∶28.6 and 1∶53.4. Conclusion Universal HBsAg in combination with ID HBV NAT screening was the most effective among all screening strategy. It is necessary to applied HBsAg and ID HBV NAT screening for the safety of blood transfusion.
Authors and Affiliations
Xianlin YE, Wen XIONG, Tong LI, Ran LI, Liqing HUANG, Jinfeng ZEN
Keywords
Related Articles
- EP ID EP738465
- DOI 10.13303/j.cjbt.issn.1004-549x.2023.01.014
- Views 2
- Downloads 0
Influencing factors of red blood cell transfusion volume for premature neonatal pneumonia and its predictive value for feeding intolerance
Objective To investigate the influencing factors of red blood cell transfusion volume for premature neonatal pneumonia and its predictive value for feeding intolerance. Methods 272 infants of premature neonatal pneumonia...
Causes of ABO forward and reverse grouping discrepancy: 75 cases
Objective To analyze the causes and solutions of ABO forward and reverse grouping discrepancy, and to ensure the safety of blood transfusion in clinical. Methods Samples from 75 patients with discrepancy between forward...
Effect of online and offline collaborative and integrated mode on voluntary blood donation: Internet + blood donation souvenir
Objective To explore the effect of online and offline collaborative and integrated mode (Internet + blood donation souvenirs), and develop diversified scientific ways of caring for voluntary blood donors in combination w...
Application evaluation of detection system based on microfluidic technology in initial screening of blood donors
Objective To evaluate the screening efficacy and practical value of the portable microfluidic biochemical analyzer in the detection of blood donors before blood donation. Methods Blood donor samples, clinical blood sampl...
Analysis of red blood cells supply before and after the outbreak of COVID-19 from 2018 to 2021 in 18 domestic blood centers
Objective To compare the supply data of red blood cells(RBCs) from 18 blood centers in China before and after the outbreak of COVID-19 during 2018 to 2021. Methods Eight indicators related to RBCs supply from 18 blood ce...