Cost-effectiveness analysis of Oral Semaglutide treatment for type 2 diabetes mellitus patients: a systematic review
Journal Title: Journal of Public Health and Development - Year 2024, Vol 22, Issue 3
Abstract
GLP-1 is a new generation of antidiabetics recommended by the American Diabetes Association and European Association for the study of diabetes as an add-on therapy for metformin when therapeutic purposes are not achieved. In this context, oral Semaglutide received FDA approval in September 2019 to be used alongside dietary and exercise regimens to enhance glycemic management in adults diagnosed with type 2 diabetes mellitus (T2DM). Therefore, this systematic review aimed to analyze cost-effectiveness of oral Semaglutide compared to other antidiabetics and/or injectable GLP-1 within the same group. Three databases namely Scopus, ScienceDirect, and PubMed were used for the literature search. Preferred Reporting Items for Systematic Review (PRISMA) guidelines were used to select the studies based on the inclusion and exclusion criteria. Quality assessment was carried out using CHEERS 2022, while the decision on cost-effectiveness was determined using the willingness-to-pay thresholds stated in each study. The results showed that from the initial search yielding 240 studies, 12 met the inclusion criteria. Oral Semaglutide was considered cost-effective compared to SGLT2 and DPP4 inhibitors, as well as injectable GLP-1 due to its higher effectiveness and lower cost.However, it was not cost-effective compared to biguanide/conventional therapy due to the higher cost. The primary sources of uncertainty in the studies were identified as time horizon, discount rate, cost, and treatment policy estimand. In conclusion, thedevelopment of oral Semaglutide represents a significant advancement in antidiabetic medications. This systematic review showed that oral Semaglutide appeared to be more cost-effective compared to other antidiabetic medications for T2DM.
Authors and Affiliations
I Kadek Suardiana, Dwi Endarti, Tuangrat Phodha
Keywords
Related Articles
- EP ID EP744908
- DOI 10.55131/jphd/2024/220322
- Views 49
- Downloads 0
Evaluation of health-seeking behaviour among older people during the COVID-19 pandemic in Bali and Yogyakarta, Indonesia
The COVID-19 pandemicposes the highest risk to older people with comorbidities, as the rapid spread of the virus reducesthe community's access to formal healthcare facilities. This leads to the search for...
Relationship of shift work with liver enzyme abnormalities and nonalcoholic fatty liver disease: A retrospective cohort study of Thai workers in Bangkok, Thailand
Shift work, particularly night shift work, has several detrimental health outcomes. This retrospective study investigated the associations of shift work with the incidence rates of liver enzyme abnormalities and nonalcoh...
Familiarity, Knowledge, Attitude and Willingness towards Genetic Counselling among the South Indian Population
The effect of any kind of genetic disorder is almost irreversible in life, so it is very important to understand these disorders and the modern, effective preventive approaches available to reduce the familial and societ...
Health determinant factors associated with smoking behaviour of older adults in Thailand
The health burden caused by smoking behaviour among older adults is an uncontrollable problem worldwide. In particular, the trend of smoking among the aging population is rapidly growing. It affects individuals, families...
Developing a tool to assess women’s knowledge and attitude toward managing prediabetes
Prediabetes is a state caused by insulin resistance, resulting in higher blood glucose levels. The incidence of diabetes mellitus can increase when this condition is not adequately treated. Therefore, this study aimed to...