COST-EFFECTIVENESS ANALYSIS OF TRASTUZUMAB IN THE TREATMENT OF METASTATIC BREAST CANCER
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 4
Abstract
Objective: To perform a cost-effectiveness analysis of pharmacological treatments for MBC in the context of the Brazilian Unified Health System (Sistema Único de Saúde - SUS) by comparing the drugs docetaxel and paclitaxel in isolation and in combination with trastuzumab.Methods: The results for each treatment were simulated using a Markov model and a hypothetical cohort of 1000 women aged 50 years diagnosed with MBC with overexpression of HER2. The progression of MBC was simulated for 48 months and the transitions between health states occurred monthly. A sensitivity analysis was performed. The discount rate considered was 5% per year.Results: The addition of trastuzumab allowed a gain of eight to ten months in the average lifespan after a four-year treatment. The increased threshold allows the increased use of trastuzumabcombined with paclitaxel in the treatment of MBC. The combinationof trastuzumabwith docetaxel and paclitaxel achieved an effective gain in the survival of patients with MBC, and the average survival time doubled compared with monotherapy.Conclusion: Considering that the costs per quality-adjusted life year (QALY) of these treatment strategies were below the threshold of 3 times the per capita GDP recommended by WHO, both strategies can be considered cost-effective.Â
Authors and Affiliations
Tayna Felicissimo G. De Souza Bandeira, Gabriela Bittencourt Gonzalez Mosegui, Cid Manso Mello Vianna, Renata Luzes Araujo, Marcus Paulo Silva Rodrigues, Paula Medeiros Valle
Keywords
Related Articles
- EP ID EP578891
- DOI -
- Views 52
- Downloads 0
MICROMORPHOLOGICAL CHARACTERIZATIONS AND PHYTOCHEMICAL CONTENTS OF SOME PHLOMIS SPECIES FROM IRAN
Objective: Microscopic characterization of a plant is a valuable method for accurate identification of the plant powder. The plants of Phlomis genus (Lamiaceae) are mostly distributed in the north and west of Iran with a...
EFFECT OF VITAMIN C ON mRNA EXPRESSION OF BMPs DURING FRACTURE HEALING IN THE FEMUR CALLUS OF SPRAGUE-DAWLEY FEMALE RATS
Fracture reparation is a complex physiological process. During fracture healing no scar is left but a new bone tissue is created. In addition to mechanical stabilization, inflammatory cytokines, growth factors, vitamins...
LIPID LOWERING ACTIVITY OF FERONIA LIMONIA LEAF IN TRITON WR-1339 (TYLOXAPOL) INDUCED HYPERLIPIDEMIC RATS
Objectives: The present study was undertaken to assess the lipid lowering activity of methanolic extract from Feronia limonia leaf in Triton WR-1339 induced hyperlipidemic rats. Methods: Hyperlipidemia was induced in rat...
CHARACTERIZATION AND ANTIFUNGAL ACTIVITY OF THE ESSENTIAL OIL OF TAGETES MINUTA FRONT OF THE CRYPTOCOCCUS SPP. ISOLATES FROM THE ENVIRONMENT
Objective: This study evaluated the chemical composition and antifungal activity of the essential oil of inflorescences of Tagetes minuta (EOTM) belonging to the Asteraceae family against Cryptococcus spp. This microorga...
PHYTOCHEMICAL EVALUATION, ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY OF HOPEA PONGA (DENNST) MABBERLY EXTRACTS
Objective: The present study was aimed at evaluating the in vitro antioxidant and antibacterial activities of methanol and aqueous extracts of Hopea ponga.Methods: Hopea ponga leaf and stem sample were powdered and extra...