Could Abnormal Distribution of Interstitial Cells of Cajal be Involved in Gastrointestinal Disorders in Patients with Parkinson’s Disease?
Journal Title: Archives in Neurology & Neuroscience (ANN) - Year 2018, Vol 1, Issue 5
Abstract
Objective: To study the role of interstitial cells of Cajal (ICC) in the pathogenesis of gastro-intestinal motility disorders in Parkinson’s disease (PD). Methods: The distribution of ICCs was studied by immunohistochemical analysis using anti c-kit antibodies in 4 cases of PD patients and 4 paired non-PD patients. Results: ICCs were located in the inner part of the circular muscle and around the myenteric plexus between the two muscle layers. The number of c-kit+ ICCs was remarkably reduced or even disappeared in patients with PD. Conclusion: The lack of ICCs may lead to the abnormal spontaneous electrical activity and conduction which gives rise to gastrointestinal motility disorders in PD.
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- EP ID EP620004
- DOI 10.33552/ANN.2018.01.000525
- Views 63
- Downloads 0
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