Could Mean Platelet Volume and Red Cell Distribution Width Predict Vitamin B12 Deficiency?
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 31
Abstract
Aims: Vitamin B12 deficiency causes an increase in homocysteine levels which is associated with inflammatory conditions. Mean platelet volume (MPV) and red cell distribution width (RDW) are also associated with inflammation. Therefore, we aimed to compare hematological parameters in patients with and without vitamin B12 deficiency to find out whether they could predict vitamin B12 deficiency. Methods: Patients who underwent vitamin B12 assessment grouped based on the serum level of vitamin B12. We grouped 116 patients, whose B12 level was lower than 250, in first group and 62 patients, whose B12 ≥ 250 pg/ml, in second group. Results: Red cell distribution width was significantly higher in group 1 (patients with a vitamin B12 level lower than 250 pg/ml) compared to those in group 2 (patients with a vitamin B12 level higher than 250 pg/ml). Mean platelet volume was significantly lower in group 1 compared to group 2. Conclusion: We suggest that MPV and RDW should be an indicator of vitamin B12 deficiency especially in early stages of the disease. However, prospective studies with larger cohort are needed to confirm our results.
Authors and Affiliations
Gulali Aktas, Aytekin Alcelik, Buket Kin Tekce, Mustafa Sit, Haluk Savli, Hikmet Tekce
Keywords
Related Articles
- EP ID EP348758
- DOI 10.9734/BJMMR/2014/12040
- Views 83
- Downloads 0
Hand Injuries in a Suburban Hospital Bayelsa State Nigeria
Aims: To determine the etiology and pattern of presentation of patient with hand injury in a semi-urban center in Bayelsa State Nigeria. Study Design: This is a retrospective study in which all the case notes of patients...
Antiatherogenic, Hypolipidemic and Antiinflammatory Benefits of Black Tea and Zanthoxylum Zanthoxyloid
The use of medicinal plants in the treatment of ailments is increasing around the globe. This study assessed the antihyperlipidemic and antiatherogenic benefits of black tea (BT) and Z. zanthoxylum (Zz) in rats. Thirty t...
Effect of Acute Placenta Inflammatory Changes on Fetal Outcome among Paturients in Nigeria
Introduction: The placenta unit is significant for the survival of the fetus. Infections from the mother can cause histologically identifiable inflammatory changes in the placenta, which may adversely affect the fetus. A...
Comparison of Subciliary, Subtarsal and Transconjunctival Approaches for Management of Zygomaticoorbital Fractures
Aims: To compare access of the surgeon and bleeding during surgery, and ectropion and scar following the surgery in subciliary, subtarsal, and transconjunctival incisions for treatment of the zygomaticoorbital region. St...
Evaluate “Rifampicin Resistance” as Surrogate Marker for Rapid Detection of MDR-TB Using Real-Time PCR Directly on FNAC Samples of Tuberculous Lymphadenitis
Background: India has the dubious distinction of having second largest burden of MDR-TB cases in the world. According to WHO, MDR-TB is defined as resistance to isoniazid and rifampicin, the two most important drugs for...