COVID 19: Camostat and the Role of Serine Protease Entry Inhibitor TMPRSS2
Journal Title: Journal of Regenerative Biology and Medicine - Year 2020, Vol 2, Issue 2
Abstract
According to the latest research, the novel coronavirus uses the protein angiotensin-converting enzyme 2 (ACE-2) as a receptor for docking to the host cell. Essential for entry is the priming of the spike (S) protein of the virus by host cell proteases. A broadly based team led by infection biologists from the German Primate Centre and with the participation of the Charité Hospital in Berlin, the Hanover Veterinary University Foundation, the BG-UnfallklinikMurnau, the LMU Munich, the Robert Koch Institute and the German Centre for Infection Research wanted to find out how SARS-CoV-2 enters host cells and how this process can be blocked [1]. They have published their findings in the journal "Cell" [1]. The team of scientists was initially able to confirm that SARS-CoV-2 docks to the host cell via the ACE-2 receptor. They also identified Transmembrane serine protease 2 (TMPRSS2) as the cellular protein responsible for entry into the cell [1-3].
Authors and Affiliations
Stefan Bittmann*, Elisabeth Luchter, Elena Moschüring-Alieva, Gloria Villalon, Anne Weissenstein
Keywords
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- EP ID EP707323
- DOI https://doi.org/10.37191/Mapsci-2582-385X-2(2)-020
- Views 73
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