COVID-19: Potential role of prophylactic anticoagulation in preventing thrombotic events and mortality. Narrative review

Journal Title: Iberoamerican Journal of Medicine - Year 2021, Vol 3, Issue 2

Abstract

The COVID-19 pandemic and the limited therapeutic arsenal available strain daily clinical practice. Guidelines have recently recommended routine anticoagulation of hospitalized COVID-19 patients. However, apart from the expert panels’ experience, the provenance of this recommendation is not clear, due to the scarce published evidence. We provide a narrative review with the objective of unraveling the rationale for this practice. First, we analyze the biochemical, histopathological and clinical evidence for a pro-thrombotic profile in COVID-19 patients. Then, we present the clinical data from previous studies and discuss to what extent they aid in clinical decision-making. We conclude that, in the absence of randomized controlled trials, which are of utmost importance, prophylactic-dose anticoagulation should be offered to critically ill patients hospitalized for COVID-19 pneumonia, particularly those with high d-dimer levels, since they are the population most likely to benefit from it.

Authors and Affiliations

Maximiliano Gabriel Castro, Gisel Cuevas

Keywords

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  • EP ID EP693825
  • DOI https://doi.org/10.5281/zenodo.4554351
  • Views 92
  • Downloads 0

How To Cite

Maximiliano Gabriel Castro, Gisel Cuevas (2021). COVID-19: Potential role of prophylactic anticoagulation in preventing thrombotic events and mortality. Narrative review. Iberoamerican Journal of Medicine, 3(2), -. https://europub.co.uk/articles/-A-693825