CREUTZFELDT-JAKOB DISEASE: A CASE REPORT
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2015, Vol 2, Issue 24
Abstract
Prion diseases are a group of fatal neurodegenerative diseases caused by the transformation of an endogenous protein, PrP (prion-related protein), into an abnormal conformation, the most common of which in humans is Creutzfeldt-Jakob disease. We report the case of a 40 year old lady who presented with rapidly progressive dementia with pyramidal, extra-pyramidal, cerebellar symptoms, myoclonus and akinetic mutism. Her EEG showed typical periodic sharp wave complexes and MRI Brain revealed DWI>FLAIR intensity in bilateral caudate nuclei, putamen & bilateral subcortical frontal lobes. The clinico-radiological correlation was consistent with the diagnosis of Creutzfeldt-Jakob disease.
Authors and Affiliations
Theophilus Premkumar V, Sooriyakumar M, Muralidharan K, Vrinda V, Kumar P
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