Critical analysis of proteinuria estimation methods in pre-eclampsia: A main research article
Journal Title: Indian Journal of Obstetrics and Gynecology Research - Year 2017, Vol 4, Issue 4
Abstract
Purpose of the study: The gold standard 24-hour urine collection method for protein estimation is inconvenient and is associated with a delay in laboratory analysis. This study was undertaken to analyse the salphosalicylic acid test, urine dip stick test, urine protein to creatinine ratio with 24-hour urine protein estimation in pre-eclampsia cases. Materials and Method: This is a comparative study and consists of a single group of 240 subjects. This study was conducted in the Department of Obstetrics and Gynecology in collaboration with the Department of Biochemistry, JIPMER, Pondicherry, India, from February 2011 to January 2014. The subjects included 240 pre-eclampsia women. A first voided morning sample was obtained for sulphosalicylic acid test, Dipstick test, urine protein and creatinine estimation, urine culture and Subsequent urine samples were collected for the 24-hour urine protein estimation. Main findings: For significant proteinuria sulphosalicylic acid test with 1+ proteinuria has sensitivity, specificity, PPV, NPV of 59%,48%,39%,67% where as 2+ has 44%, 88%, 75% and 67% respectively, dipstick test with 1+ proteinuria has sensitivity, specificity, PPV, NPV of 71%, 52%, 54%,70% where as 2+ has 49%, 87%, 75% and 69% respectively. The spot urine protein to creatinine ratio and 24-hour urine protein were significantly correlated (r=0.98; P<0.0001). The cut-off value for the protein to creatinine ratio as an indicator of protein excretion ≥300 mg/day was 0.285. The sensitivity, specificity PPV and NPV were 100%, 99.02%, 100% and 99% respectively. Conclusion: The spot urine protein to creatinine ratio is a better method for estimation of proteinuria in pre-eclampsia. Funding: No Funding body, corresponding author himself bear the necessary expenses.
Authors and Affiliations
Hanumant V. Nipanal, Susmitha Shivanna Reddy, Dilip Kumar Maurrya, Ravindra Pattanashetti Nagendra
Keywords
Related Articles
- EP ID EP315116
- DOI 10.18231/2394-2754.2017.0080
- Views 82
- Downloads 0
Contraceptive awareness, and practices among rural women in Lucknow
Objective This cross sectional observational study was done to asses awareness regarding family planning methods and the practice of contraceptives among rural women in LucknowMaterials and Methods Five hundred women bet...
A comparative study of combination of intracervical foley's catheter and intravaginal misoprostol versus intravaginal misoprostol alone for induction of labour
Aims & Objective: The goal of induction of labour is to achieve vaginal delivery in a safe timely manner, to prevent unnecessary LSCS and for safe neonatal outcome. The main objective of this study is to compare combinat...
Supraclavicular lymph node involvement in endometrial carcinoma, rare site of metastasis: A case report
Endometrial carcinoma is one of the commonest gynecological cancers of female genital tract usually occurring after menopause Supraclavicular lymph node is one of the rare sites of metastasis in the endometrial carcinoma...
Diagnostic dilemmas in ectopic pregnancy
Aim of the study: To find out the atypical presentations of ectopic pregnancy that had lead to delay in diagnosing cases of ectopic pregnancy leading to increased morbidity and sometimes mortality. Study design: It is a...
Hypertensive disorders of pregnancy and its effect on the placenta in Indian women
Objective The main objective of the present study is to grossly examine the placenta of normotensive and hypertensive pregnanciesStudy Design A prospective casecontrol observational study designed was used in current stu...