Crude Leaf Extracts of Psidium Guajava Could Potentially be Used in Treatment of Type 1 Diabetes
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2014, Vol 4, Issue 4
Abstract
The antidiabetic potential of Psidium guajava ethanolic leaf extract was investigated in Wistar albino rats. Type 1 diabetes model was induced in the rats using Alloxan monohydrate (120 mg/kg) intraperitoneally. The extract was administered orally, daily for 21 days at 200, 400, 600 and 800mg/kg body weight in groups 1, 2, 3 and 4 (n=5) respectively. Glibenclamide (50 mg/kg) was orally administered to group 5 as positive control while distilled water (1ml) was given to group 6 as negative control. Tail clipping was done at 7 day intervals and blood glucose levels determined. There was a time and dose dependent reduction in blood glucose levels of treated diabetic rats. The percent reduction in blood glucose level for the different treatment groups after 21 days was 57%, 64%, 65%, 78% and 84% for 200, 400, 600, 800mg/kg extracts and Glibenclamide respectively. At days 14 and 21 post-treatment there was no significant difference (p>0.05) between the mean percent glucose reduction in rats treated with 600 mg/kg or 800 mg/kg of the extract and the group treated with glibenclamide indicating that the extract showed a high degree of antidiabetic activity. The high LD50 of the extract (9,922 mg/kg) in mice shows that the plant extract is non-toxic and safe to use since the value was found to be much higher than 5000 mg/kg as provided by OECD guideline 423.
Authors and Affiliations
J. N. Kateregga , E. Wambua , P. Vudriko , J. G. Ndukui , W. Evans
Keywords
Related Articles
- EP ID EP157748
- DOI -
- Views 92
- Downloads 0
Effects of Hydrogen Sulfide on Oxidative Stress, TNF-α Level and Kidney Histological Changes in Cisplatin Nephrotoxicity in Rat
Cisplatin (CP) is an anticancer drug that enhances renal generation of reactive oxygen metabolites, lipid peroxidation and inflammation. This study examined the effect of hydrogen sulfide on lipid peroxidation content, t...
Effects of Water Crude Leaf Extract of Moringa Oleifera Lam (Moringaceae) on Normotensive Rat Blood Pressure and Isolated Duodenum
Moringa oleifera is used in folk medicine for the treatment of many ailments among which, hypertension and intestinal disorders. The aim of this study was to investigate the hypotensive and/or antihypertensive activity o...
Knowledge, Attitude, Practice and Determinants of Condom Use Among People Living With HIV/AIDS in Gondar University Hospital, North West Ethiopia
Condoms offer protection against unwanted pregnancy and some sexually transmitted infections including HIV. Interventions to promote condom use are essential in efforts to slow the spread of HIV. The burden of HIV/AIDS i...
Pre-Implantation Effects of the Root Bark of Adansonia Digitata Linn in Female Wistar rats
To investigate the pre-implantation effects of Adansonia digitata root bark extract, which is used traditionally for antifertility purposes and known to have uterotropic effects. Four groups, comprised of twelve (12) pre...
Benefits of Lutein and Zeaxanthin Intake in Patients with Age-Related Macular Degeneration, Retinitis Pigmentosa and Cataracts
Research data indicate that lutein and zeaxanthin intake can alleviate symptoms of different eye pathologies. Within the retina, lutein and zeaxanthin are concentrated in the macula, with as much as 25% of their total re...