Crystal and Molecular Docking Studies of 3-[Bis-(2- Hydroxy-4,4-Dimethyl-6-Oxo-Cyclohex-1-Enyl)-Methyl]Benzonitrile with Focal Adhesion Kinase Inhibitors
Journal Title: Archives of Organic and Inorganic Chemical Sciences - Year 2018, Vol 1, Issue 3
Abstract
Cyclohexane is found naturally to some extent in petroleum but is prepared commercially by catalytic hydrogenation of benzene.It is widely used as a solvent and in making certain compounds used in the preparation of nylon. The biological importance of cyclohexane has resulted in the synthesis of substituted derivatives which show potent pharmaceutical activities like antimicrobial, ant diabetic, anticancer antipsychotic, anesthetic, expectorant activities [1]. Focal adhesion kinase is a cytoplasmic non-receptor protein tyrosine kinase which was isolated for the first time by co- immunoprecipitation of tyrosine-phosphorylated proteins from cells transformed with Rous sarcoma virus v-Src. Non-receptor protein-tyrosine kinase (PTK2/FAK1) that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. It is required for early embryonic and placenta development. It also required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. It regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. It plays a role in osteogenesis and differentiation of osteoblasts. It helps in function of integrin signal transduction, but also in signaling downstream of numerous growth factor receptors
Authors and Affiliations
KS Kiran, Kokila MK, Guruprasad R, Prashantha k
Keywords
Related Articles
- EP ID EP598665
- DOI 10.32474/AOICS.2018.01.000114
- Views 46
- Downloads 0
Prerequisites for Addressing the Development of Soil Erosion in Sloping Lands of Azerbaijan
The article examines the issues of the possibility of studying the areas of development by soil erosion and its control. The study proved that the development of soil erosion is based on the forming impact of natural and...
Heavy Metals Removal from Wastewater by Adsorption on Modified Physically Activated Sewage Sludge
Low cost adsorbent (activated carbon) with a high metal adsorption capacity was prepared from the disposal sewage sludge by physical activation method (Pyrolysis temperatures at 500 °C, 650 °C, 700 °C, 800 °C and 900 °C)...
The Carbonyl Groups as Scaffolds in Coordination Chemistry
Carbonyl compounds are of paramount importance in the formation of C-C bonds and metal-ion control of their reactivity offers a way to promote, inhibit, or control such reactions [1]. The co...
Enhanced Arsenic Contents in Spring Water within the Engadine Valley (South-eastern Switzerland; Canton of Graubünden)
Enhanced arsenic contents were observed (at the Chemical laboratory of the Canton Graubunden in Chur) in the water of some mountainous springs of the Upper Engadine Valley in the vicinity the alpine resort of St. Moritz....
On Efficiency of Application of Irrigation Systems With Low Intensity at Azerbaijan’s Slot Land
The study of the world experience and the results of long-term experiments on drip irrigation systems in various climatic and soil conditions shows that the creation of irrigation systems of this type is effective and ec...