Crystal and Molecular Docking Studies of 3-[Bis-(2- Hydroxy-4,4-Dimethyl-6-Oxo-Cyclohex-1-Enyl)-Methyl]Benzonitrile with Focal Adhesion Kinase Inhibitors
Journal Title: Archives of Organic and Inorganic Chemical Sciences - Year 2018, Vol 1, Issue 3
Abstract
Cyclohexane is found naturally to some extent in petroleum but is prepared commercially by catalytic hydrogenation of benzene.It is widely used as a solvent and in making certain compounds used in the preparation of nylon. The biological importance of cyclohexane has resulted in the synthesis of substituted derivatives which show potent pharmaceutical activities like antimicrobial, ant diabetic, anticancer antipsychotic, anesthetic, expectorant activities [1]. Focal adhesion kinase is a cytoplasmic non-receptor protein tyrosine kinase which was isolated for the first time by co- immunoprecipitation of tyrosine-phosphorylated proteins from cells transformed with Rous sarcoma virus v-Src. Non-receptor protein-tyrosine kinase (PTK2/FAK1) that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. It is required for early embryonic and placenta development. It also required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. It regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. It plays a role in osteogenesis and differentiation of osteoblasts. It helps in function of integrin signal transduction, but also in signaling downstream of numerous growth factor receptors
Authors and Affiliations
KS Kiran, Kokila MK, Guruprasad R, Prashantha k
Keywords
Related Articles
- EP ID EP598665
- DOI 10.32474/AOICS.2018.01.000114
- Views 56
- Downloads 0
Advanced Oxidation Processes (AOPs) by Bismuth Oxyhalides for Environmental Remediation Using Solar Energy: Enhancing Material Property through Synthesis
To combat air and water pollution with green chemistry is one of the major issues. Several research groups, worldwide, are today engaged in the design and development of new photocatalytic materials which can act to make...
Antimicrobial Properties of Plants of Chungtia Village Used Customarily to Treat Skin Related Ailments: From Antimicrobial Screening to Isolation of Active Compounds
Ethno pharmacological relevance: Chungtia villagers of Nagaland, India, have a strong reliance on plants as medicines. Previous studies have shown that 31 Chungtia medicinal plants (and parts therein) used customarily fo...
Dependence of Cadmium Sulfide Fluorescence on the Excitation Light Energy
Monotonic dependence ofthe fluorescence band position on the exciting light energy has been shown in polycrystalline hexagonal cadmium sulfide at 293 K. The observed phenomenon is interpreted on the basis of a qualitativ...
Improved Enantioselective Enzymatic Synthesis of (S) - Pregabalin
Pregabalin is available in the market under the brand name of Lyrica among others. It is a drug of choice for the treatment of epilepsy, fibromyalgia, sweeping anxiety disorder and neuropathic pai...
Computational Studies of the Corrosion Inhibition Potentials of Quercetin and Coumarin
The molecules of Coumarin and Quercetin were subjected to computational calculations using the Density Functional Theory (DFT) in order investigate their inhibition potentials. The Coumarin molecule demonstrated a greate...