Crystal and Molecular Docking Studies of 3-[Bis-(2- Hydroxy-4,4-Dimethyl-6-Oxo-Cyclohex-1-Enyl)-Methyl]Benzonitrile with Focal Adhesion Kinase Inhibitors
Journal Title: Archives of Organic and Inorganic Chemical Sciences - Year 2018, Vol 1, Issue 3
Abstract
Cyclohexane is found naturally to some extent in petroleum but is prepared commercially by catalytic hydrogenation of benzene.It is widely used as a solvent and in making certain compounds used in the preparation of nylon. The biological importance of cyclohexane has resulted in the synthesis of substituted derivatives which show potent pharmaceutical activities like antimicrobial, ant diabetic, anticancer antipsychotic, anesthetic, expectorant activities [1]. Focal adhesion kinase is a cytoplasmic non-receptor protein tyrosine kinase which was isolated for the first time by co- immunoprecipitation of tyrosine-phosphorylated proteins from cells transformed with Rous sarcoma virus v-Src. Non-receptor protein-tyrosine kinase (PTK2/FAK1) that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. It is required for early embryonic and placenta development. It also required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. It regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. It plays a role in osteogenesis and differentiation of osteoblasts. It helps in function of integrin signal transduction, but also in signaling downstream of numerous growth factor receptors
Authors and Affiliations
KS Kiran, Kokila MK, Guruprasad R, Prashantha k
Keywords
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- EP ID EP598665
- DOI 10.32474/AOICS.2018.01.000114
- Views 58
- Downloads 0
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