CSF LACTATE IN MENINGITIS
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 43
Abstract
BACKGROUND Meningitis is an infection within the subarachnoid space characterised by a CNS inflammatory reaction. It is a serious condition requiring immediate diagnosis and appropriate treatment to be started at the earliest to prevent mortality as well as irreversible neurological deficits. CSF lactate has been found useful in differentiating bacterial meningitis from viral meningitis in many studies in the western population, but studies in Indian population are limited. The aim of the study is to study whether CSF lactate can be used to distinguish bacterial from viral meningitis and to study the levels of CSF lactate in tuberculosis meningitis. MATERIALS AND METHODS This was a descriptive study conducted in a tertiary care hospital. In this study, 78 cases of meningitis were selected. Cases are patients with bacterial, viral or tuberculosis meningitis admitted to the hospital under the Department of Medicine and Neurology. Cases are grouped into bacterial, viral and tuberculosis meningitis based on clinical picture, CSF analysis and imaging characteristics. CSF lactate estimation was done by dry chemistry method. Using appropriate statistical methods and SPSS software, CSF lactate levels were compared among these groups and analysed for any association with the final outcome. RESULTS The levels of CSF lactate in bacterial meningitis were higher than viral meningitis with a statistical significance of p <0.0001. The sensitivity and specificity of CSF lactate >35 mg/dL for bacterial meningitis in this study was 95% and 100% respectively and the positive predictive value was 100% and the negative predictive value was 96%. The mean CSF lactate values in bacterial, viral and tuberculosis meningitis were 124.40 ± 35.85 mg/dL, 24.34 ± 6.05 mg/dL and 50.13 ± 9.89 mg/dL, respectively. CONCLUSION CSF lactate level was significantly elevated in bacterial meningitis than tuberculosis or viral meningitis and can be used as a marker for differentiating bacterial from viral meningitis.
Authors and Affiliations
Anjampakuthikal Aboobekar Haris, Rajeev Abraham, Jacob George
Keywords
Related Articles
- EP ID EP219930
- DOI 10.18410/jebmh/2017/526
- Views 62
- Downloads 0
A CLINICAL STUDY OF EFFECTS OF POLY AND OLIGOHYDROMNIOS ON OBSTETRIC OUTCOME WITH A SPECIAL REFERENCE TO PERINATAL MORTALITY AND MORBIDITY
To study the obstetric outcome in pregnancies with oligohydramnios and polyhydramnios. To determine the perinatal outcome in pregnancies complicated with oligohydramnios and polyhydramnios. METHODS: This study is conduct...
BONE MARROW BIOPSY IN EVALUATION OF HAEMATOLOGICAL DISORDERS
BACKGROUND Bone Marrow Trephine Biopsy (BMTB) and aspiration is critical for diagnosis, prognostic evaluation and monitoring therapeutic response. BMTB is of greater value in assessing cellularity, degree of fibrosis, ma...
SNAKE BITE WITH TOXIC DEMYELINATION – A CASE REPORT
INTRODUCTION Snakebite is an important cause of mortality and morbidity in India. India has the highest number of deaths due to snake bite1 Neurotoxicity due to snakebite is well-known with varied presentation.2 Common c...
SMALL CELL VARIANT OF OSTEOSARCOMA AT DIAPHYSIS OF TIBIA: A RARE CASE REPORT WITH REVIEW OF LITERATURE
Osteosarcoma is the most common primary malignant tumor of bone involving predominantly metaphysis of the long bones. It accounts for 20% of primary bone cancers. Diaphyseal osteosarcoma is a rare form which accounts for...
EFFECT OF AGE AND BODY MASS INDEX ON SENSORY NERVE CONDUCTION
BACKGROUND Nerve Conduction Study (NCS) and Needle Electromyography (EMG) are the main electrodiagnostic assessments for peripheral nerves. Nerve conduction study helps in knowing the extent and distribution of neural le...