CT manifestations and clinical characteristics of pulmonary invasive mucinous adenocarcinoma
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 1
Abstract
<b>Objective</b> To investigate the CT imaging manifestations and clinicopathologic features of patients with primary pulmonary invasive mucinous adenocarcinoma (PIMA) diagnosed pathologically after surgery. <b>Methods</b> The clinical data of 78 patients with PIMA diagnosed pathologically after surgery in the Department of Thoracic Surgery of Anhui Chest Hospital from November 2019 to November 2021 were retrospectively analyzed. <b>Results</b> Among the 78 cases, 33 (42.3%) were male and 45 (57.7%) were female，aged (60.3±7.8) years in total, and serum carcinoembryonic antigen (CEA) was increased (＞5 ng/mL) in 9 cases (11.5%). According to the clinical characteristics, patients could be divided into the asymptomatic group (60 cases, 76.9%) and the symptomatic group (18 cases, 23.1%). The symptomatic group included 8 cases with coughing and coughing up mucus sputum, 4 cases with chest tightness and chest and back pain, and 6 cases with other symptoms. Imaging manifestations showed that 51 (65.4%) lesions were located in the inferior lobes of both lungs and 71 (91.0%) in the peripulmonary,of which 46 patients (59.0%) had completely solid nodules, and common signs included shallow lobulation and vascular cluster sign. Postoperative pathologic stages Ⅰ, Ⅱ, Ⅲa were found in 61 (78.2%), 9 (11.5%) and 8 (10.3%) patients, respectively. Moreover, genetic testing was performed in 13 patients, of which 8 cases were detected with mutations of Kirsten rat sarcoma viral oncogene (KRAS), and 1 case was detected with mutations of epidermal growth factor receptor (EGFR) gene. Twenty-two patients were tested for the expression of programmed death-ligand 1 (PD-L1), and 18 (81.8%) of these patients had a tumor proportional score (TPS) of＜1%. <b>Conclusion</b> Except for expectoration of mucous sputum, PIMA has no specific clinical symptoms. CT manifestations show that the lesions usually occur in the inferior lobes and peripulmonary of the lungs, and most pulmonary nodules are completely solid, which with signs of shallow lobulation and vascular cluster. Laboratory tests show that the expression level of PD-L1 is low, and the KRAS mutations are relatively more frequent. These features have some value in the diagnosis and differential diagnosis of PIMA.
Authors and Affiliations
WANG Baoming, DAI Chen, MA Dongchun
Keywords
Related Articles
- EP ID EP735803
- DOI 10.13429/j.cnki.cjcr.2024.01.011
- Views 68
- Downloads 0
Impact of forward-extension and backward-extension nursing protocols on perioperative complications and disease cognition in patients undergoing thoracoscopic radical resection for lung cancer
Objective To explore the influence of forward-extension and backward-extension nursing protocols on the incidence of perioperative complications and disease awareness levels in patients undergoing thoracoscopic lung canc...
Research progress of regorafenib in the treatment of colorectal cancer
Colorectal cancer (CRC) is a common malignant tumor of digestive tract with an increasing incidence and mortality worldwide, and most patients have lost the opportunity of surgical treatment once diagnosed. With the cont...
Factors associated with the severity of coronary artery disease in type 2 diabetes mellitus patients
Objective To analyze the factors related to the severity of coronary artery disease (CAD) in type 2 diabetes mellitus (T2DM) patients, with the aim of providing a reference for the risk assessment of them. Methods Clinic...
Three-dimensional evaluation of the anatomy of the mental foramen region by cone-beam CT in patients with malocclusion
Objective To investigate the differences in anatomical structures of the mandibular mental foramen region in patients with bony class Ⅱand class Ⅲ malocclusions. Methods Preoperative CBCT images of 256 patients who under...
Effect of subanesthetic dose of esketamine on perioperative hemodynamics in patients undergoing lumbar surgery under general anesthesia
Objective To analyze the effect of subanesthetic dose of esketamine on perioperative hemodynamics and adverse events in patients undergoing lumbar spine surgery under general anesthesia. Methods The clinical data of 70...