Culturing of Marine Sponges and Extraction of Antibiotics from Sponges Collected from Bay of Bengal
Journal Title: International Journal for Research in Applied Science and Engineering Technology (IJRASET) - Year 2017, Vol 5, Issue 6
Abstract
Marine sponges are a rich source of bioactive compounds with pharmaceutical Potential. Since biological production is one option to supply materials for early rug development, the main challenge is to establish generic techniques for Small-scale production of marine organisms. We analyzed the state of the art for cultivation of whole sponges, sponge cells and sponge symbionts. To date, Cultivation of whole sponges has been most successful in situ; however, optimal Conditions are species specific. The establishment of sponge cell lines has Been limited by the inability to obtain an anemic inoculums as well as the lack of Knowledge on nutritional requirements in vitro. Approaches to overcome these bottlenecks, including transformation of sponge cells and using media base on yolk, are elaborated. Although a number of bioactive metabolite-producing Microorganisms have been isolated from sponges, and it has been suggested that the source of most sponge-derived bioactive compounds is microbial Symbionts, cultivation of sponge-specific microorganisms has had limited success. The current genomics revolution provides novel approaches to cultiva these microorganisms.
Authors and Affiliations
Srinivasan Balakrishnan
Keywords
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