Curative strategies in acute myeloid leukemia in younger adults

Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2005, Vol 22, Issue 3

Abstract

The treatment of acute myeloid leukemia (ΑML) generally involves the administration of cytotoxic chemotherapy to eradicate the malignant cells, which permits restoration of normal hematopoiesis by normal residual stem cells. The outcome for adults with AML depends not only on the age of the patient but also on the intensity of post-remission therapy and on the biologic characteristics of the disease, including the karyotype and the expression of the multidrug resistant (mdr) phenotype. The French-American-British (FAB) classification allows the uniformity of diagnosis at morphologic subtypes of AML. The new WHO classification correlates morphology, cytochemistry, immunophenotype, karyotype, and molecular genetics with clinical features. Improvements in outcome have been achieved primarily because of better supportive care, post-remission intensive chemotherapy (IC), autologous stem cell transplantation (auto-SCT) or allogeneic stem cell transplantation (allo-SCT). Patients with standard-risk disease have traditionally been referred for a matched sibling allograft if a donor is available and the patient's performance status is adequate. In recent years, chemotherapy postremission has improved outcome, with 50% 5-year overall survival (OS) and 40% disease-free survival

Authors and Affiliations

N. ANAGNOSTOPOULOS

Keywords

Related Articles

Criteria and processes for evaluating qualitative research methodology in health studies

In the field of health sciences, only during the last decades has there been a growing interest in the applicability of qualitative research methodology. Concurrently, a debate began about the scientific value of qualit...

The complicated labour and death of Empress Eudoxia at 6.10.404 a.D.

The Byzantine Empress Eudoxia's seventh birthing was fatal due to the complications that occurred following intrauterine fetal death. The rapid deterioration of her clinical condition and the lack of immediate medical in...

Osteoid osteoma

No abstract available

Pleuropulmonary blastoma

No abstract available

Download PDF file
  • EP ID EP133945
  • DOI -
  • Views 108
  • Downloads 0

How To Cite

N. ANAGNOSTOPOULOS (2005). Curative strategies in acute myeloid leukemia in younger adults . Αρχεία Ελληνικής Ιατρικής, 22(3), 221-238. https://europub.co.uk/articles/-A-133945