Curcumin as a Bioactive Component
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 17, Issue 6
Abstract
Curcumin, a bioactive polyphenol found in the plant Curcuma longa is a natural supplement available worldwide. Curcumin has been recognized for its anti-oxidant and anti-inflammatory properties for a number of years. Further, its therapeutic potential has been demonstrated in animal studies and clinical trials. Numerous reports exist on the mechanisms of action by which curcumin can protect against those chronic diseases associated with oxidative stress and inflammation. Several studies have addressed the effects of curcumin on Alzherimer’s disease, type 2 diabetes, cardiovascular diseases and asthma. Although, curcumin has been shown to directly affect inflammatory pathways and production of inflammatory cytokines as well as to effectively scavenge free radicals and improve endothelial function, a number of clinical trials have failed to demonstrate efficiency due to its poor bioavailability, physicochemical instability and rapid metabolism. The use of nanoencapsulation to improve delivery of curcumin to target tissues suggests that nanodelivery could increase the healing efficiency of curcumin. In this review, the therapeutic potential of curcumin to protect against chronic disease and the underlying mechanisms will be discussed.
Authors and Affiliations
Siqi Hu, Maria Luz Fernandez
Keywords
Related Articles
- EP ID EP341867
- DOI 10.9734/BJMMR/2016/28370
- Views 59
- Downloads 0
Appreciating the Essence of Post Natal Care Services from Mothers’ Perspective in Kiambu, Kenya
Introduction: The first 42 days after delivery is a critical period in the lives of mothers and newborn babies. Most maternal and infant deaths occur during this time. The government of Kenya has recommended that all...
Evidence Based Approach to Perthes
Perthes is a self-limiting disorder of paediatric hip. The outcome of this disorder is variable. Every aspect of it including, etiology, pathogenesis, pathology, classification, natural course, management and outcome is...
Birth Control Pills: Profile of Acceptors at University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria
Background: Oral contraceptives are among the earliest, safest, and most common method of fertility control especially in the developed countries. However, there is paucity of data on birth control pills in Sub-Saharan A...
Risk Factors for First-line Antiretroviral Treatment Failure in HIV-1 Infected Children Attending Jos University Teaching Hospital, Jos, North Central Nigeria
Aim: To determine risk factors for first-line antiretroviral treatment failure in HIV-1 infected children attending Jos University Teaching Hospital, Jos. Study Design: Retrospective cohort study. Place and Duration of...
A 66 Patient Multi-Institution Phase IV Post-Authorization Surveillance of ProThelial™ (High Potency Polymerized Cross-linked Sucralfate) -Single Agent Efficacy for the Prevention and Rapid Reversal of Chemo-radiation Induced Oral, Esophageal and Intestinal Mucositis
Background: Standard potency sucralfate is not recommended by most clinical guidelines for prevention or treatment of oral and intestinal mucositis. However, its polymerized cross-linked (thereby high potency) formulatio...