Curcumin in The Treatment of in Animals Myocardial ischemia reperfusion: A Systematic review and Meta-analysis
Journal Title: Medical Data Mining - Year 2019, Vol 2, Issue 2
Abstract
Objective: The protective effects of curcumin on myocardial ischemia-reperfusion were systematically evaluated by analyzing the related literatures of curcumin and myocardial ischemia-reperfusion. Methods: The computer was searched for Wanfang, VIP, China National Knowledge Infrastructure(CNKI), SinoMed, and Pubmed database to find animal experiments on curcumin treatment of myocardial ischemia-reperfusion.The retrieval time is from the establishment of the database to November 2018. Two researchers independently screened the literature based on inclusion and exclusion criteria, extracted the data, and assessed the risk of bias in the included studies. Meta analysis was performed using RevMan 5.3 software. Results: Finally, 9 studies were included for analysis. Meta-analysis showed that the curcumin group can reduce LDH and MDA levels compared with the ischemiar-reperfusion group (LDH: SMD=-4.75, 95% CI [-6.56, -2.94], P < 0.01, MDA: SMD=-2.27, 95% CI [-3.07, -1.47], P < 0.01), the difference was statistically significant (P<0.01). In the subgroup analysis of different doses of curcumin, different doses of curcumin (0.8, 10, 12.5, 20, 25, 30, 50 mg) were able to reduce LDH content compared with the ischemia-reperfusion group, and the differences were statistically significant. Different doses of curcumin (5,10,20,30,40mg) can reduce MDA content, and the difference is statistically significant; curcumin (0.8mg) group has no statistically significant effect on MDA content (SMD = -0.54, 95% CI [-1.35, 0.28], P = 0.20). The relationship between the content of MDA and the dose of curcumin showed that compared with the curcumin (20 mg) group, the curcumin (40 mg) group could better reduce the MDA content, and the difference was statistically significant (P=0.03). Conclusion: Curcumin can reduce the content of LDH and MDA in myocardial ischemia-reperfusion, and has a protective effect on myocardium. Moreover, the ability to reduce the damage is related to the dose of curcumin. However, the sample of the included studies is limited, and this conclusion requires more high-quality experiments to verify.
Authors and Affiliations
Qian He1, Bin Meng1, Hong-Yun Hu1, Gao-Jian Zhuang1, Qun Tang1, Xu Zhu1*
Keywords
Related Articles
- EP ID EP710381
- DOI -
- Views 42
- Downloads 0
Efficacy of empowerment education in self-management with Type 2 Diabetes Mellitus: A systematic review and meta-analysis
Objective: To evaluate the impact of empowerment education in self-management with Type 2 Diabetes Mellitus. Methods: A literature search was performed in PubMed, Web of Science, Cochrane Library, Embase, China National...
A study on the rule of Chinese medicine use against influenza virus based on data mining
Background: To summarize the rules of the use of traditional Chinese medicine against influenza virus in the high-quality literatures of core journals, and to provide guidance for the prevention and treatment of influenz...
Traditional Chinese Medicine for Bladder Cancer: a Systematic Review and Meta-Analysis
Objective: To evaluate the efficacy and safety of traditional Chinese medicine in the treatment of bladder cancer. Methods: The databases of CNKI (1989-2018.10), Wan fang Data (1989-2018.10), VIP (1989-2018.10), PubMed (...
Association rules analysis of Fufang Kushen injection in combination with traditional Chinese medicine or modern medications in treating Cervical cancer: real-world retrospective study
Objective: The present study aimed to analyze the association rules of Fufang Kushen injection in combination with other traditional Chinese medicine (TCM) or modern medications in treating cervical cancer (CC) based on...
The research progress of acupuncture and moxibustion in the treatment of peripheral facial paralysis
As a common and frequently-occurring disease in clinic, peripheral facial paralysis is worth paying attention to. In fact, as one of the methods for the treatment of peripheral facial paralysis, acupuncture has been wide...