Current approaches to the treatment of endometrial hyperplasia in women with uterine leiomyoma
Journal Title: Медичні перспективи - Year 2014, Vol 19, Issue 3
Abstract
The study involved 155 women, of which 30 healthy women were in the control group. 125 women with uterine leiomyomas and endometrial hyperplasia constituted the main groups. In all women with uterine leiomyoma myomectomy was performed. Further treatment included randomized study of a new regimen of GnRH agonists together with COCs after myomectomy using comparison techniques: monotherapy with a-GnRH, progestins (dydrogesterone) or COCs. The treatment using different medication regimens of endometrial hyperplasia after myomectomy convincingly demonstrated significantly greater efficacy of GnRH-a and COCs combination in reducing frequency of symptoms of these diseases, volume of menstrual blood loss and improvement quality of life through the entire observation period. Greater efficacy of COCs and a-GnRH combination, to our opinion, is associated with a greater degree of suppression of cell proliferation and angiogenesis as a result of local (COCs), and systemic effects (a-GnRH).Thus, the proposed method of adjuvant therapy after myomectomy for women with associated endometrial hyperplasia has significant clinical benefits with minimal impact on bone mineral density and other menopausal signs caused by a-GnRH monotherapy.
Authors and Affiliations
V. Potapov, Yu. Donskaya, M. Medvediev
Keywords
Related Articles
- EP ID EP142327
- DOI -
- Views 105
- Downloads 0
Peculiarities of systemic violations in patients with genital endometriosis in combination with benign diseases of genitalia and syndrome of chronic pelvic pain
The aim of the work is determination of intercommunication of cytokines ІL-10, ІL-6 levels, TNF-α with subjective estimation of pain, processes of the nervous system desadaptation in patients with genital endometriosis i...
Репродуктивне здоров’я чоловіків промислових територій: фактори ризику, донозологічна діагностика, профілактика
Ухудшение состояния окружающей среды в XX-XXI веке под влиянием химических, физических, радиационных и ряда других факторов является не только и не столько экологической катастрофой современности, сколько непосредственно...
Експресія генів нуклеарного фактора активованих Т-клітин у дітей з двостулковим аортальним клапаном серця
Гены нуклеарного фактора активированных Т- клеток (NFATC) играют ключевую роль как в формировании клапанов сердца, та и в имуннном ответе. В экспериментальных моделях также показано, что данные гены, относящиеся к факто...
General characteristics of dental morbidity in children against orthodontic treatment
A wide spread of orthodontic treatment showed a fairly high risk of complications developed from the use of various devices. The aim of our study was to determine the general characteristics of dental morbidity in childr...
Ідентифікація спеціальних компетентностей магістра в галузі стоматології: проект
В статье рассматривается проблема идентификации специальных компетентностей магистра стоматологической отрасли. Представлены результаты анализа отечественных и зарубежных научных источников, нормативно-правовых документ...