Current Evaluation for the Frequency of Portal Vein Thrombosis and Its Impact among Egyptian Cirrhotic Patients
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 8
Abstract
Background: Development of portal vein thrombosis (PVT) is a significant milestone in the natural history of cirrhosi. Aim of the Study: Evaluation of frequency of portal vein thrombosis in cirrhotic patients, determine the possible associated risk factors and consequence of portal vein thrombosis in cirrhotic patients. Patients and Methods: The present study was conducted on 500 cirrhotic patients. All patients were subjected to routine investigations, upper gastrointestinal endoscopy and abdominal ultrsonography with portal doppler examination. Results: The present study revealed portal vein thrombosis (PVT) in 89 patients with frequency 17.8% of PVT among cirrhotic patients. Hepatocellular carcinoma (HCC) was the commonest risk factors of portal vein thrombosis followed by sclerotherapy. Hepatitis C was present in 88.8% of patients with portal vein thrombosis. Elevated liver enzymes, bilirubin and alpha fetoprotein were significantly increased in patients with PVT in comparison with those without PVT. Child C class showed highly statistically significant increase in patients with portal vein thrombosis. The incidence of portal vein thrombosis in cirrhotic patients www.jmscr.igmpublication.org Impact Factor 3.79 ISSN (e)-2347-176x Soha E. Khorshed et al JMSCR Volume 2 Issue 8 August 2014 Page 1949 JMSCR Volume||2||Issue||8||Page 1948-1952||August-2014 2014 who underwent splenectomy was 50%. Portal vein and spleenic diameter,were significantly increased in patients with PVT in comparison with those without PVT. Retrograde flow, distention and increased echogenicity at the site of the thrombus in addition to cavernous transformation were significantly observed on Doppler examination of patients with PVT. Conclusions: PVT is frequently reported in patients with liver cirrhosis especially those with advanced stages as a part from a complex scenario. HCC and sclerotherapy are the most common risk factors of PVT.
Authors and Affiliations
Soha E. Khorshed
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