Cutaneous Adverse Drug Reactions in a Tertiary Care Hospital: An Observational Study
Journal Title: Journal of Pharmacovigilance and Drug Research - Year 2020, Vol 1, Issue 20201101
Abstract
Cutaneous adverse drug reactions (CADRs) are one of the most common ADRs caused by drugs causing a lot of morbidity and mortality. The overall incidence of CADRs in developed countries is 1-3 %, while that in the developing countries is reported to be higher between 2 % and 5 %. Changes in drug metabolism drug interactions, oxidative stress, and various cytokines are the various factors that cause cutaneous adverse drug reactions. This study aims to evaluate the patterns of CADRs, the causative drugs along with causality and severity assessment. A total of 50 Patients with cutaneous adverse drug reactions who were included in our last study attended skin OPD, VIMSAR Burla, from June 2018 to September 2018 and were analyzed for causality assessment using the WHO-UMC scale and severity assessment using Hartwig and Siegel's scale. Out of 50 patients, 48 % belong to the age group 21-40 years. Around 44 % of CADRs were fixed drug eruptions. NSAID was found to be the most offending drug and it contributed to a maximum 32 % of ADRs. 16 % of ADRs were found to be caused by antitubercular drugs. Paracetamol was the key NSAID, contributing 87.5 % of ADRs. Causality was certain, probable, and possible for 8 %, 24 %, and 60 % of ADRs respectively. Severity was mild for 64 % and moderate for 34 % of ADRs. NSAID and antitubercular drugs are the commonest drugs causing CADRs. Fixed drug eruption is the most common CADRs and the commonest drug was paracetamol. Causality grade was possible and the severity grade was mild.
Authors and Affiliations
Baijayanti Rath 1, Manas Ranjan Naik 1, Bhabagrahi Rath 1, Renuka Bhoi 1*, Jai Prakash4
Keywords
Related Articles
- EP ID EP690847
- DOI 10.5281/zenodo.4016642
- Views 187
- Downloads 1
Artificial Neural Network: A Data Mining Tool in Pharmacovigilance
Pharmacovigilance ensures patients safety as well as drug safety. In India, there is still a lot to be done and learned to ensure that the work and activities done in the area of pharmacovigilance are safely implemented....
Overview of important methods used for Causality Assessment of adverse drug events in Pharmacovigilance
The method of assessing causality between adverse events and suspect drugs is the most challenging task in pharmacovigilance. It requires attentive consideration of both the adverse events and suspect drugs, patient-rela...
Cutaneous Adverse Drug Reactions in a Tertiary Care Hospital: An Observational Study
Cutaneous adverse drug reactions (CADRs) are one of the most common ADRs caused by drugs causing a lot of morbidity and mortality. The overall incidence of CADRs in developed countries is 1-3 %, while that in the develop...
Drug Related Problems on Anti-platelets and Anti-coagulants in Stroke
The aim of the research work is to access, evaluate and monitor the drug related problems on antiplatelet and anticoagulants in stroke patients. Antiplatelet agents prevent platelets from dumping and prevent clots from f...
Metformin related adverse events: A prospective observational study in health care centers of western Odisha
The study was done to explore the management of the patients having diabetes by primary care physicians, and the adverse reactions associated with the dose regimens. A qualitative In-Depth Interview study was conducted a...