Cutaneous Drug Reactions Reported In a Dermatology Outpatient Clinic of a Tertiary Care Hospital
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 5
Abstract
Background:Cutaneous adverse drug reactions (CADR) are the most frequent serious adverse reactions reported in outpatient department of dermatology. Objective:The aim of the study to assess the prevalence and clinical spectrum of CADR among patients and to assess causality and identify the offending drugs. Materials and Methods:An observational study was undertaken over12month’speriod (Dec 2013- Dec 2014) in Dermatology OPD of tertiary care teaching hospital in GOVT. GENERAL HOSPITAL, KAKINADA, ANDHRA PRADESH by ADR card reporting. Drug history was recorded in a format specified in Indian National Pharmacovigilance Program and causality assessment carried out as per WHO-UMC criteria. Results:Study showed that, ADR reported among 522 total, 217 (41.5%) were CADRs. These CADR are mostly seen in gender female & age group between 18-45 years. Group of drugs leading to above manifestations are Antimicrobials-48.3%, NSAIDS -19.3%, Steroids- 5.5%, Others -26.7%. CADR manifestations: Maculopapular rash- 26.3%, Photosensitivity- 21.2%, Urticaria- 17.5%, Bullous eruptions –12.0%, Severe Mucositis-10.1%, Pruritis – 5.1%, Fixed drug eruption –2.8 %, Stevens–Johnson Syndrome (SJS)- 1.8%, Toxic Epidermal Necrolysis (TEN)- 1.8%, Erythema multiformae-1.4%. Causality assessment was Certain 33.6%, Probable 16.1% and Possible 50.2% of the reactions. Conclusion: CADRs are utmost necessity for a physician to have understanding, as well as knowledge of the drugs essential for diagnosis and prevention.
Authors and Affiliations
Swathi Ratnam . R, K. ChandraMouli Krishna
Keywords
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- EP ID EP374836
- DOI 10.9790/0853-1705083340.
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