CXC Ligand 5 cytokine serum level in women with polycystic ovary syndrome and normal body mass index: A case-control study
Journal Title: International Journal of Reproductive BioMedicine - Year 2017, Vol 15, Issue 10
Abstract
Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disease and associated with insulin resistance. CXC Ligand 5 (CXCL5) is a new cytokine which is secreted from white adipose tissue during obesity and by blocking insulin signaling pathway inhibits the activity of insulin and promotes insulin resistance. Objective: The aim of this study was to assess serum level of CXCL5 in PCOS women with normal body mass index. Materials and Methods: In this case-control study, 30 PCOS women with normal body mass index as the case group and 30 non-PCOS women as the controls were enrolled. Serum levels of CXCL5, insulin and other hormones factors related with PCOS were measured by ELISA method, also the biochemical parameters were measured by autoanalyzer. Results: Significant increases in serum insulin concentration, homeostasis model assessments of insulin resistance, luteinizing hormone, luteinizing hormone/folliclestimulating hormone, fasting blood sugar, testosterone, and prolactin were observed in the case group compared to the controls. were in the serum level of CXCL5, cholesterol, low-density lipoprotein-cholesterol, high-density lipoproteincholesterol, dehydroepiandrosterone-sulfate, creatinine, and homeostasis model assessment of beta cell function between these two groups. Conclusion: In this study, no significant change was observed in serum concentrations of CXCL5 in PCOS women with normal BMI.
Authors and Affiliations
Marzieh Zohrabi, Elham Rahmani, Niloofar Motamed, Samad Akbarzadeh
Keywords
Related Articles
- EP ID EP281279
- DOI 10.29252/ijrm.15.10.4
- Views 106
- Downloads 0
Correlation between follicular fluid 25-OH vitamin D and assisted reproductive outcomes
Background: Vitamin D in complex with its receptor by regulating gene expression, endometrium immune response and stimulation of endometrium decidualization can be involved in implantation. So, it seems that the amount o...
Age-specific nomograms for follicle stimulating hormone and anti-Mullerian hormone: A pilot study in Ile-Ife, Nigeria
Background: Assessment of ovarian reserve is one of the steps in the management of infertile couples. Follicle Stimulating hormone (FSH) and anti-Müllerian hormone (AMH) are commonly used ovarian reserve markers in Afric...
Protective effect of green tea extract on the deltamethrin-induced toxicity in mice testis: An experimental study
Background: Deltamethrin (DM) is one of the environmental factors that can have destructive effects on the male fertility. Green tea (GT) as a medicinal herb, has antioxidant property. Objective: The present study invest...
Granulocyte colony-stimulating factor and reproductive medicine: A review
Background: Recently, the use of granulocyte colony-stimulating factor (G-CSF) has been proposed to improve pregnancy outcomes in reproductive medicine. Objective: A systematic review of the current use of G-CSF in pati...
GnRH agonist trigger versus hCG trigger in GnRH antagonist in IVF/ICSI cycles: A review article
Routinely, a bolus of 5.000-10.000 IU human chorionic gonadotropin (hCG) is used for the final follicular maturation and ovulation as a standard method. HCG has the same effect of luteinizing hormone (LH) with long half-...