Cyathula prostrata: A Potential Herbal Hope for Hypertensives, an Animal Model Study and Its Secondary Metabolites Assessment via GC-MS
Journal Title: European Journal of Medicinal Plants - Year 2016, Vol 14, Issue 2
Abstract
Aim: The use of folkloric therapy in the management of ailments such a hypertension is a global phenomena. Extracts of Cyathula prostrata are used as alternate antihypertensive in Nigeria. This paper evaluated the scientific basis for such use. Study Design: The study involved using rat model. High blood pressure was simulated in the rat via induction with adrenaline, while another group of rats was used without adrenaline administration. Aqueous and ethanolic extracts of the Cyathula prostrata were administered to the different rat sets. The work was carried out in Lagos, Nigeria in the second half of 2015. Methodology: Cyathula prostrata extracts was administered in graded doses of 50, 100 and 150 mg/kg body weight to the different groups of animals. The presence of secondary metabolites in the extracts was assessed using standard phytochemistry techniques and verified using GC-MS. Results: A total of 13 plant secondary metabolites were identified by GC-MS. Cyathula prostrata extracts effected a marked decrease in the measured blood pressure parameters of adrenaline induced hypertensive rats evaluated in this study. Conclusion: In this study, orally administered Cyathula prostrata extracts reduced high blood pressure parameters in adrenaline induced hypertensive rats, with the most likely effectors being the secondary metabolites present in this extract. The outcome of this baseline study potentially validates the folkloric use of the extract as antihypertensives.
Authors and Affiliations
Anthony B. Ojekale, Oladipupo A. Lawal, Malik O. Lasisi
Keywords
Related Articles
- EP ID EP349691
- DOI 10.9734/EJMP/2016/25007
- Views 111
- Downloads 0
Pharmacological Activities of Agave seemanniana and Isolation of Three Steroidal Saponins
Aim: To investigate the analgesic, anti-inflammatory and ulceroprotective properties of Agave seemanniana methanolic leaf extract (MEAS) and its saponin containing fraction (SFAS), in animal models compared to standard d...
Renal Protective Properties of Aqueous Extract of Bryophyllum pinnatum (Lam.) Oken Leaf against Petrol Vapour – Induced Toxicity on Male Albino Rats
The aim of this study was to investigate the renal protective properties of aqueous leaf extract of Bryophyllum pinnatum from Nigeria against petrol vapour – induced toxicity on the kidney of male albino rats. Fifty appa...
Comparative Antibacterial and Antifungal Efficacy of Selected Tanzania Medicinal Plants
Aims: To evaluate the antimicrobial activity of Crassocephalum vitellinum (Benth), Euphorbia hirta (L), Cupressus lusitanica (Mill), Euphorbia inaquilatera (Sond), Ajuga remota (Benth) and Lantana camara (linn) extracts...
Isolation and Characterizations of Bergenin from Peltophorum pterocarpum Leaves and Its Cholinesterase Inhibitory Activities
Aims: The study identified a cholinesterase inhibitory constituent in P. pterocarpum, a medicinal plant used in Nigerian ethno-medicine for the management of memory loss. Study Design: Activity directed phytochemical inv...
Hepatoprotective Activity of Rubia tinctorum’s Extract against CCl4 Induced Hepatic Injury in Rats
This study investigated the hepatoprotective activity of Rubia tinctorum’s extract against CCl4 induced liver damage in rats. Twenty four rats were divided into four groups. Group I received normal saline (10 ml/kg) and...